University of Washington School of Medicine.
Department of Medicine.
Open Forum Infect Dis. 2015 Sep 19;2(4):ofv140. doi: 10.1093/ofid/ofv140. eCollection 2015 Dec.
Hemophagocytic lymphohistiocytosis (HLH) in immunocompromised hosts is a fulminant syndrome of immune activation with high rates of mortality that may be triggered by infections or immunodeficiency. Rapid diagnosis and treatment of the underlying disorder is necessary to prevent progression to multiorgan failure and death. We report a case of HLH in a patient with human immunodeficiency virus, disseminated histoplasmosis, Mycobacterium avium complex, and Escherichia coli bacteremia. We discuss management of acutely ill patients with HLH and treatment of the underlying infection versus initiation of HLH-specific chemotherapy.
免疫功能低下宿主中的噬血细胞性淋巴组织细胞增生症（HLH）是一种免疫激活的暴发性综合征，死亡率较高，可能由感染或免疫缺陷引发。为了防止多器官衰竭和死亡，必须迅速诊断和治疗潜在疾病。我们报告了一例人类免疫缺陷病毒、播散性组织胞浆菌病、鸟分枝杆菌复合体和大肠杆菌菌血症患者的 HLH 病例。我们讨论了 HLH 急危重症患者的处理方法，以及针对潜在感染的治疗与 HLH 特异性化疗的启动。
