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免疫功能正常患者播散性组织胞浆菌病继发噬血细胞性淋巴组织细胞增生症。

Haemophagocytic lymphohistiocytosis secondary to disseminated histoplasmosis in an immunocompetent patient.

作者信息

Morton Mallory, Vanguru Vinay, Shin Joo-Shik, Ronnachit Amrita

机构信息

Department of Infectious Diseases, Royal Prince Alfred Hospital, Sydney, NSW, 2050, Australia.

Department of Medicine, Campbelltown Hospital, Campbelltown, NSW, 2560, Australia.

出版信息

Med Mycol Case Rep. 2024 Feb 18;43:100635. doi: 10.1016/j.mmcr.2024.100635. eCollection 2024 Mar.

DOI:10.1016/j.mmcr.2024.100635
PMID:38425787
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10904178/
Abstract

Haemophagocytic lymphohistiocytosis secondary to infection is rare and almost always occurs in immunocompromised hosts. We report a 32-year-old immunocompetent man presenting with a nonspecific febrile illness found to have disseminated histoplasmosis and associated haemophagocytic lymphohistiocytosis. The diagnosis was confirmed on histopathological examination and PCR of liver and bone marrow biopsies. He was successfully treated with steroids, intravenous immunoglobulin and itraconazole.

摘要

继发于感染的噬血细胞性淋巴组织细胞增生症罕见，几乎总是发生在免疫功能低下的宿主中。我们报告一例32岁免疫功能正常的男性，表现为非特异性发热性疾病，被发现患有播散性组织胞浆菌病及相关的噬血细胞性淋巴组织细胞增生症。通过肝脏和骨髓活检的组织病理学检查及聚合酶链反应确诊。他接受类固醇、静脉注射免疫球蛋白和伊曲康唑治疗后痊愈。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ef/10904178/94b79608d613/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ef/10904178/94b79608d613/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ef/10904178/94b79608d613/gr1.jpg

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2
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Infect Dis Now. 2021 May;51(3):308-309. doi: 10.1016/j.medmal.2020.09.019. Epub 2020 Oct 7.
3
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