Simon P
J Pharmacol. 1985 Jan-Mar;16(1):1-5.
Fourteen french pharmacologists working for the pharmaceutical industry were asked about the tests they used for the primary screening and the study of hypnotic drugs. They were also asked about the tests using interactions between hypnotics and the studied drugs, either psychotropic or not. The results of survey are presented. A systematic study was performed concerning the interaction of psychotropic drugs with either barbital or pentobarbital in mice. The utilization of these two tests is useful for the research of possible inductory or inhibitory effect on hepatic enzymatic systems. For a complete study of drugs with a profile of psychostimulant or antidepressant.
十四位在制药行业工作的法国药理学家被问及他们用于催眠药物初步筛选和研究的测试。他们还被问及使用催眠药与所研究药物（无论是否为精神药物）之间相互作用的测试。现将调查结果呈现如下。针对精神药物与巴比妥或戊巴比妥在小鼠体内的相互作用进行了系统研究。这两种测试的应用有助于研究对肝酶系统可能的诱导或抑制作用。以便对具有精神兴奋或抗抑郁特性的药物进行全面研究。
