Dave Amartya, Santos Raquel Dos, Siddiqi Usmaan, Dharia Aashi, Li Willa, Siddiqi Umar, Nguyen Nhung, Pocivavsek Luka, Hibino Narutoshi
Section of Cardiac Surgery, Department of Surgery, The University of Chicago, Chicago, IL 60637, USA.
School of Medicine, University of California, San Francisco, CA 94143, USA.
J Cardiovasc Dev Dis. 2025 Feb 13;12(2):70. doi: 10.3390/jcdd12020070.
Computational fluid dynamics (CFD) is a tool that allows for the analysis of otherwise unobservable blood flow patterns. In the context of medicine, CFD enables researchers to better understand acute and chronic pathophysiology as well as utilize modeling tools to predict blood flow patterns in response to surgical intervention. Such a tool is particularly useful in the field of congenital heart disease (CHD), where complex geometries and patient-specific pathology are common. Research applying CFD to study CHDs has significantly grown in the last twenty years, with new methodologies and recommendations being published at an even faster pace in the last decade. Many currently available reviews are focused on a particular area of progress or on the technical approaches to CFD geared toward the clinician. This review focuses on CFD application within the major domains of CHD research, specifically single ventricle defects and aortic coarctation, reviewing consensus seminal work while highlighting more recent avenues of study. Balancing discussion of CFD parameters with potential clinical implications of study results, this review not only aims to provide cardiovascular professionals context for the technical advancements being made in the field but also a sense of contemporary CFD's utility in clinical practice.
计算流体动力学（CFD）是一种工具，可用于分析原本无法观察到的血流模式。在医学领域，CFD使研究人员能够更好地理解急性和慢性病理生理学，并利用建模工具预测手术干预后的血流模式。这种工具在先天性心脏病（CHD）领域特别有用，因为复杂的几何结构和特定患者的病理情况很常见。在过去二十年中，应用CFD研究CHD的研究显著增加，在过去十年中，新的方法和建议的发表速度甚至更快。许多现有的综述都集中在特定的进展领域或针对临床医生的CFD技术方法上。本综述重点关注CFD在CHD研究主要领域的应用，特别是单心室缺陷和主动脉缩窄，回顾了具有代表性的共识性工作，同时突出了最新的研究途径。本综述在讨论CFD参数的同时，兼顾研究结果的潜在临床意义，不仅旨在为心血管专业人员提供该领域技术进展的背景信息，还旨在让他们了解当代CFD在临床实践中的效用。
