No information is available on the use of epcoritamab during breastfeeding. Because epcoritamab is a large protein molecule with a molecular weight of about 149,000 Da, the amount in milk is likely to be very low.[1] It is also likely to be partially destroyed in the infant's gastrointestinal tract and absorption by the infant is probably minimal.[2] The manufacturer recommends that breastfeeding be discontinued during therapy and 4 months after the last dose.
关于在母乳喂养期间使用依泊妥单抗的信息尚无可用资料。由于依泊妥单抗是一种分子量约为149,000道尔顿的大蛋白质分子,乳汁中的含量可能非常低。[1]它也可能在婴儿胃肠道中部分被破坏,婴儿的吸收可能极少。[2]制造商建议在治疗期间以及最后一剂后4个月内停止母乳喂养。