2024年7月至12月异种移植文献更新
Xenotransplantation Literature Update July-December 2024.
作者信息
Shirini Kasra, Ladowski Joseph M, Meier Raphael P H
机构信息
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Department of Surgery, Duke University School of Medicine, Durham, North Carolina, USA.
出版信息
Xenotransplantation. 2025 Jan-Feb;32(1):e70027. doi: 10.1111/xen.70027.
Abstract
This review highlights groundbreaking progress from July to December 2024, including developments in gene-edited pigs, cellular therapies, organ preservation, and transplantation techniques. Recent advancements, particularly in gene-editing technologies and immunosuppressive protocols, have brought the field closer to clinical application. While significant ethical, immunological, and societal challenges remain, this progress underscores the immense potential of xenotransplantation to revolutionize transplantation medicine.
摘要
本综述重点介绍了2024年7月至12月的突破性进展，包括基因编辑猪、细胞疗法、器官保存和移植技术的发展。最近的进展，特别是在基因编辑技术和免疫抑制方案方面，使该领域更接近临床应用。虽然重大的伦理、免疫和社会挑战仍然存在，但这一进展凸显了异种移植在彻底改变移植医学方面的巨大潜力。
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本文引用的文献
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Anterior retroperitoneal approach in constructing thymokidney organs in swine for xenotransplantation.猪异种移植中构建胸腺肾器官的腹膜前入路。
Front Transplant. 2024 Nov 14;3:1473281. doi: 10.3389/frtra.2024.1473281. eCollection 2024.
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Pig Xenotransplantation in Beta Cell Replacement: Addressing Challenges and Harnessing Potential for Type 1 Diabetes Therapy.猪异种移植在胰岛细胞替代治疗中的应用：应对挑战与挖掘 1 型糖尿病治疗潜能
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3
Prevalence of Antibodies against Adeno-Associated Viruses (AAVs) in Göttingen Minipigs and Its Implications for Gene Therapy and Xenotransplantation.在哥廷根小型猪中抗腺相关病毒（AAV）抗体的流行情况及其对基因治疗和异种移植的影响。
Viruses. 2024 Oct 15;16(10):1613. doi: 10.3390/v16101613.
4
Pediatric Cardiac Xenotransplantation and Expanded Access: Ethical Considerations.儿科心脏异种移植和扩大准入：伦理考虑。
Pediatr Transplant. 2024 Nov;28(7):e14876. doi: 10.1111/petr.14876.
5
Offline: Xenotransplantation-a new era beckons.线下：异种移植——一个新时代即将来临。
Lancet. 2024 Sep 28;404(10459):1181. doi: 10.1016/S0140-6736(24)02130-5.
6
Who shall go first? A multicriteria approach to patient selection for first clinical trials of cardiac xenotransplantation.谁应率先接受治疗？心脏异种移植首次临床试验患者选择的多标准方法。
J Med Ethics. 2025 Feb 21;51(3):156-162. doi: 10.1136/jme-2024-110056.
7
Extended survival of 9- and 10-gene-edited pig heart xenografts with ischemia minimization and CD154 costimulation blockade-based immunosuppression.缺血最小化和基于 CD154 共刺激阻断的免疫抑制可延长 9 种和 10 种基因编辑猪心脏移植物的存活时间。
J Heart Lung Transplant. 2024 Dec;43(12):1932-1944. doi: 10.1016/j.healun.2024.07.022. Epub 2024 Aug 7.
8
An Approach to Controlling Inflammation and Coagulation in Pig-to-Baboon Cardiac Xenotransplantation.控制猪-狒狒心脏异种移植中炎症和凝血的方法。
Xenotransplantation. 2024 Jul-Aug;31(4):e12877. doi: 10.1111/xen.12877.
9
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Am J Transplant. 2024 Nov;24(11):2066-2079. doi: 10.1016/j.ajt.2024.07.018. Epub 2024 Jul 23.
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