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本文引用的文献

1
Enhanced restoration of visual code after targeting ON bipolar cells compared with retinal ganglion cells with optogenetic therapy.与采用光遗传学疗法靶向视网膜神经节细胞相比,靶向视锥双极细胞后视觉编码的恢复得到增强。
Mol Ther. 2025 Mar 5;33(3):1264-1281. doi: 10.1016/j.ymthe.2025.01.030. Epub 2025 Jan 17.
2
An Optical Coherence Tomography-Based Measure as an Independent Estimate of Retinal Function in Retinitis Pigmentosa.一种基于光学相干断层扫描的测量方法作为视网膜色素变性视网膜功能的独立评估指标。
Diagnostics (Basel). 2023 Nov 24;13(23):3521. doi: 10.3390/diagnostics13233521.
3
Optogenetic Vision Restoration.光遗传学视觉恢复。
Cold Spring Harb Perspect Med. 2024 Aug 1;14(8):a041660. doi: 10.1101/cshperspect.a041660.
4
Current Status of Clinical Trials Design and Outcomes in Retinal Gene Therapy.视网膜基因治疗临床试验设计和结果的现状。
Cold Spring Harb Perspect Med. 2024 Jul 1;14(7):a041301. doi: 10.1101/cshperspect.a041301.
5
Persistent remodeling and neurodegeneration in late-stage retinal degeneration.晚期视网膜变性中的持续重塑和神经退行性变。
Prog Retin Eye Res. 2020 Jan;74:100771. doi: 10.1016/j.preteyeres.2019.07.004. Epub 2019 Jul 26.
6
Visual Cortical Plasticity in Retinitis Pigmentosa.视网膜色素变性的视皮层可塑性。
Invest Ophthalmol Vis Sci. 2019 Jun 3;60(7):2753-2763. doi: 10.1167/iovs.18-25750.
7
Red-shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina.红移通道视紫红质刺激可恢复盲鼠、猕猴视网膜和人类视网膜中的光反应。
EMBO Mol Med. 2016 Nov 2;8(11):1248-1264. doi: 10.15252/emmm.201505699. Print 2016 Nov.
8
Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration.靶向ON双极细胞的光激活通道可恢复视网膜变性中的视觉功能。
Nat Neurosci. 2008 Jun;11(6):667-75. doi: 10.1038/nn.2117. Epub 2008 Apr 27.
9
Adaptive coding of visual information in neural populations.神经群体中视觉信息的自适应编码。
Nature. 2008 Mar 13;452(7184):220-4. doi: 10.1038/nature06563.
10
Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration.微生物型视紫红质的异位表达可恢复光感受器退化小鼠的视觉反应。
Neuron. 2006 Apr 6;50(1):23-33. doi: 10.1016/j.neuron.2006.02.026.

Turning ON the inner retinal circuity: An exciting new approach to optogenetic therapy.

作者信息

Rosin Boris, Sahel Jose-Alain

机构信息

Department of Ophthalmology/UPMC Vision Institute, University of Pittsburgh, Pittsburgh, PA, USA.

Department of Ophthalmology/UPMC Vision Institute, University of Pittsburgh, Pittsburgh, PA, USA.

出版信息

Mol Ther. 2025 Mar 5;33(3):840-841. doi: 10.1016/j.ymthe.2025.02.011. Epub 2025 Feb 24.

DOI:10.1016/j.ymthe.2025.02.011
PMID:39999834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11897766/
Abstract
摘要