Choi Su Jin, So Min Wook, Lee Sunggun, Choi Seung Won, Lim Doo-Ho
Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.
Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, South Korea.
Arch Iran Med. 2025 Jan 1;28(1):40-43. doi: 10.34172/aim.31804.
In contrast to experimental studies indicating the neuroprotective role of uric acid (UA), recent clinical studies have shown that increased UA is associated with a risk of acute hemorrhagic stroke. However, the association of UA with intraventricular hemorrhage (IVH) has not been adequately evaluated. In this study, we determined the relationship between UA and IVH in patients with intracerebral hemorrhage (ICH). We included 721 patients with ICH who were admitted to a tertiary hospital in South Korea. The patients were stratified into quartiles based on their UA levels. IVH decreased continuously across all quartiles of UA. After adjusting for confounding factors, the odds ratio (OR) for IVH was significantly lower in the fourth quartile compared with that in the first quartile (OR: 0.713; 95% CI: 0.546-0.934; =0.045). In conclusion, UA is independently associated with IVH, suggesting its protective role against IVH in patients with ICH.
与表明尿酸（UA）具有神经保护作用的实验研究相反，近期的临床研究显示，尿酸水平升高与急性出血性中风风险相关。然而，尿酸与脑室内出血（IVH）之间的关联尚未得到充分评估。在本研究中，我们确定了脑出血（ICH）患者中尿酸与脑室内出血之间的关系。我们纳入了721名入住韩国一家三级医院的脑出血患者。根据尿酸水平将患者分为四分位数。在所有尿酸四分位数中，脑室内出血发生率持续下降。在调整混杂因素后，与第一四分位数相比，第四四分位数发生脑室内出血的比值比（OR）显著降低（OR：0.713；95%置信区间：0.546 - 0.934；P = 0.045）。总之，尿酸与脑室内出血独立相关，提示其在脑出血患者中对脑室内出血具有保护作用。
