Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Neurol Sci. 2014 Jul;35(7):1035-9. doi: 10.1007/s10072-014-1634-7. Epub 2014 Jan 25.
Cerebral amyloid angiopathy (CAA) is a common degenerative disease presenting intracerebral hemorrhage (ICH) in older people. Uric acid (UA) is a natural antioxidant, and may have a beneficial role in neurodegenerative diseases. Nevertheless, the role of UA in CAA remains unknown. In the present study, we compared serum UA levels in CAA-associated ICH patients (n = 82) and age/sex-matched controls (n = 82). Serum UA levels in possible CAA were significantly decreased when compared with healthy controls (232.68 ± 77.70 vs. 309.42 ± 59.83 μmol/L; p < 0.001). Furthermore, UA levels in patients clinically diagnosed as probable CAA were significantly lower than those in patients diagnosed as possible CAA (193.06 ± 56.98 vs. 232.68 ± 77.70 μmol/L; p = 0.014). These differences were still significant after adjusting for renal function and dyslipidemia (p < 0.001 and p = 0.002, respectively). However, there were no associations between serum UA levels and the distribution of hemorrhagic lesion, as well as neurological impairment. Our observations indicate that serum UA levels were decreased in CAA patients. UA might play a neuroprotective role in CAA and serve as a potential biomarker for reflecting the severity of Aβ deposition.
脑淀粉样血管病（Cerebral amyloid angiopathy，CAA）是一种常见的退行性疾病，可导致老年人发生颅内出血（Intracerebral hemorrhage，ICH）。尿酸（Uric acid，UA）是一种天然的抗氧化剂，可能在神经退行性疾病中发挥有益作用。然而，UA 在 CAA 中的作用尚不清楚。在本研究中，我们比较了 CAA 相关 ICH 患者（n = 82）和年龄/性别匹配的对照组（n = 82）的血清 UA 水平。与健康对照组相比，可能的 CAA 患者的血清 UA 水平显著降低（232.68 ± 77.70 与 309.42 ± 59.83 μmol/L；p < 0.001）。此外，临床诊断为可能的 CAA 患者的 UA 水平明显低于临床诊断为可能的 CAA 患者（193.06 ± 56.98 与 232.68 ± 77.70 μmol/L；p = 0.014）。调整肾功能和血脂异常后，这些差异仍然显著（p < 0.001 和 p = 0.002）。然而，血清 UA 水平与出血病变的分布以及神经功能缺损之间没有相关性。我们的观察结果表明，CAA 患者的血清 UA 水平降低。UA 可能在 CAA 中发挥神经保护作用，并可能作为反映 Aβ 沉积严重程度的潜在生物标志物。
