Jerzsele Ákos, Szabó Ábel, Barnácz Franciska, Csirmaz Bence, Kovács László, Kerek Ádám
Department of Pharmacology and Toxicology, University of Veterinary Medicine, István Utca 2, H-1078 Budapest, Hungary.
National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, University of Veterinary Medicine, István Utca 2, H-1078 Budapest, Hungary.
Antibiotics (Basel). 2025 Feb 11;14(2):176. doi: 10.3390/antibiotics14020176.
: The global spread of antimicrobial resistance (AMR) necessitates collaborative approaches between animals, their environment, and public health sectors, fostering the One Health concept. () is a zoonotic, facultative pathogenic bacterium. Its public health significance underlines the need for the regular monitoring of different strains causing clinical disease, especially in poultry, more specifically in chickens, which have become a critical source of animal protein. : The antimicrobial susceptibility of 133 strains isolated from clinical cases in large-scale Hungarian poultry between 2022 and 2023 was assessed via the gold-standard minimum inhibitory concentration (MIC) determination, which provides internationally comparable results. : Our findings revealed high resistance levels to widely used antibiotics, including amoxicillin (57.9%), neomycin (78.9%), doxycycline (46.6%), and potentiated sulfonamides (43.6%). Resistance to these critically important antibiotics is particularly concerning due to their public health significance. Comparison with regional human resistance data revealed similar patterns for β-lactam antibiotics; however, aminoglycosides, fluoroquinolones, and potentiated sulfonamides exhibited significantly higher resistance levels in veterinary isolates. : Our results highlight the importance of routine surveillance, which has both veterinary and public health implications. Future efforts to correlate antibiotic usage with resistance patterns and to elucidate the genetic background of multidrug-resistant strains will further strengthen the One Health approach.
抗菌药物耐药性（AMR）在全球范围内的传播使得动物、其生存环境和公共卫生部门之间需要采取协作方法，以促进“同一健康”理念。（）是一种人畜共患的兼性病原菌。其对公共卫生的重要性凸显了定期监测引起临床疾病的不同菌株的必要性，特别是在家禽中，更具体地说是在鸡中，鸡已成为动物蛋白的重要来源。：通过金标准最小抑菌浓度（MIC）测定评估了2022年至2023年从匈牙利大型家禽临床病例中分离出的133株菌株的抗菌药物敏感性，该方法可提供国际可比的结果。：我们的研究结果显示，对广泛使用的抗生素，包括阿莫西林（57.9%）、新霉素（78.9%）、强力霉素（46.6%）和增效磺胺类药物（43.6%），耐药水平较高。由于这些至关重要的抗生素对公共卫生具有重要意义，对它们的耐药性尤其令人担忧。与区域人类耐药数据的比较显示，β-内酰胺类抗生素的耐药模式相似；然而，氨基糖苷类、氟喹诺酮类和增效磺胺类药物在兽医分离株中的耐药水平显著更高。：我们的结果强调了常规监测的重要性，这对兽医和公共卫生都有影响。未来将抗生素使用情况与耐药模式相关联以及阐明多重耐药菌株遗传背景的努力将进一步加强“同一健康”方法。
