Pharmacogenetics and Pharmacokinetics of Moxifloxacin in MDR-TB Patients in Indonesia: Analysis for and .

: Studies show that SNPs in rs2032582 and rs4149015 affect the PK profile of moxifloxacin, a key drug for MDR-TB. This study aimed to assess the genotype frequencies of rs2032582 and rs4149015; describe moxifloxacin AUC and C; and evaluate the association between genotype variations and moxifloxacin AUC and C, corrected for the effect of other determinants in MDR-TB patients in Indonesia. : The genotypes were identified using DNA sequencing. Plasma samples for PK analysis were collected at either two or four timepoints post-dose, at steady state. AUC values were assessed with a limited sampling formula. A multivariate linear regression analysis identified the determinants for moxifloxacin AUC and C. : We recruited 204 MDR-TB patients for PG analysis, with 80 providing PK samples. The majority of the and genotypes were wildtype (GG), 41.7% and 93.6%, respectively. The geometric mean AUC for moxifloxacin was 78.6 mg·h/L and that for C was 6.1 mg/L. No statistically significant difference in exposure to moxifloxacin could be shown between the genotypes. Sex, age, and dose in mg/kg/body weight were significant determinants of the AUC of moxifloxacin. : The major genotype of rs2032582 and rs4149015 was wildtype, and the exposure to moxifloxacin was high but not related to the studied genotype in an Indonesian population.