Biopharmaceutical Research and Development Center, College of Life Science and Technology, Jinan University, Guangzhou 510632, Guangdong, China.
Peptides. 2012 Oct;37(2):207-15. doi: 10.1016/j.peptides.2012.07.001. Epub 2012 Jul 16.
Antimicrobial peptides (AMPs), which are produced by several species including insects, other animals, micro-organisms and synthesis, are a critical component of the natural defense system. With the growing problem of pathogenic organisms resistant to conventional antibiotics, especially with the emergence of NDM-1, there is increased interest in the pharmacological application of AMPs. They can protect against a broad array of infectious agents, such as bacteria, fungi, parasite, virus and cancer cells. AMPs have a very good future in the application in pharmaceuticals industry and food additive. This review focuses on the AMPs from different origins in these recent years, and discusses their various functions and relative mechanisms of action. It will provide some detailed files for clinical research of pharmaceuticals industry and food additive in application.
抗菌肽（AMPs）是由多种物种产生的，包括昆虫、其他动物、微生物和合成物，是天然防御系统的重要组成部分。随着对传统抗生素具有抗药性的致病生物体问题的日益严重，特别是 NDM-1 的出现，人们对 AMP 的药理学应用越来越感兴趣。它们可以预防广泛的感染源，如细菌、真菌、寄生虫、病毒和癌细胞。AMPs 在制药工业和食品添加剂中的应用前景非常广阔。本综述重点介绍了近年来不同来源的 AMPs，并讨论了它们的各种功能和相关的作用机制。它将为制药工业和食品添加剂的临床研究提供一些详细的文件。
