Danpanichkul Pojsakorn, Pang Yanfang, Diaz Luis Antonio, Arab Juan Pablo, Hwang Soo Young, Dejvajara Disatorn, Suresh Varshini, Suenghataiphorn Thanathip, Wannaphut Chalothorn, Suparan Kanokphong, Wijarnpreecha Karn, Kim Hyunseok, Kim Donghee, Singal Amit G, Yang Ju Dong
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79409, USA.
Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533099, China.
Cancers (Basel). 2025 Feb 11;17(4):609. doi: 10.3390/cancers17040609.
BACKGROUND/OBJECTIVES: The incidence and mortality of early-onset cancers have been rising in recent decades. While epidemiological studies have examined various types of cancer, updated global data on alcohol-attributable primary liver cancer (PLC) in young adults remains limited.
This study utilized data from the Global Burden of Disease (GBD) study spanning 2000 to 2021 to evaluate the age-standardized incidence, mortality, and corresponding rates of alcohol-attributable PLC among young adults aged 15-49 years.
In 2021, there were 8290 incidence cases and 6590 deaths from alcohol-attributable PLC in young adults. The age-standardized incidence rate has increased in Europe (annual percent change [APC]: 0.44%, 95%CI 0.35 to 0.54%), Southeast Asia (APC: 0.40%, 95% CI 0.37 to 0.44%), and the Western Pacific region (APC: 0.65%, 95% CI 0.44 to 0.86%). In 2021, alcohol-attributable PLC in young adults represented 11% (+2% from 2000) of incident cases and 11% of (+2% from 2000) deaths among all PLC in young adults. About half of the countries showed an increase in the age-standardized incidence rate of alcohol-attributable PLC among young adults between 2000 and 2021.
The incidence rate of alcohol-attributable liver cancer in young adults has shifted significantly over the past two decades, with notable increases in Europe and the Asia-Pacific region. This trend underscores the need for global strategies to address the rising prevalence of alcohol use disorder and alcohol-associated liver disease and their impact on young adults.
背景/目的：近几十年来，早发性癌症的发病率和死亡率一直在上升。虽然流行病学研究已经考察了各种类型的癌症，但关于年轻人中酒精所致原发性肝癌（PLC）的最新全球数据仍然有限。
本研究利用了全球疾病负担（GBD）研究中2000年至2021年的数据，以评估15至49岁年轻人中酒精所致PLC的年龄标准化发病率、死亡率及相应比率。
2021年，年轻人中酒精所致PLC的发病病例有8290例，死亡6590例。欧洲（年变化百分比[APC]：0.44%，95%可信区间0.35至0.54%）、东南亚（APC：0.40%，95%可信区间0.37至0.44%）和西太平洋地区（APC：0.65%，95%可信区间0.44至0.86%）的年龄标准化发病率有所上升。2021年，年轻人中酒精所致PLC占所有年轻人PLC发病病例的11%（比2000年增加2%），占死亡病例的11%（比2000年增加2%）。约一半的国家在2000年至2021年间年轻人中酒精所致PLC的年龄标准化发病率有所上升。
在过去二十年中，年轻人中酒精所致肝癌的发病率发生了显著变化，欧洲和亚太地区有明显上升。这一趋势凸显了制定全球战略以应对酒精使用障碍和酒精相关肝病患病率上升及其对年轻人影响的必要性。
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