Danpanichkul Pojsakorn, Pang Yanfang, Suparan Kanokphong, Auttapracha Thanida, Sirimangklanurak Supapitch, Attia Abdelrahman M, Thimphitthaya Chanattha, Ni Law Michelle Shi, Yu Zhenning, Soliman Mostafa A, Polpichai Natchaya, Kanitthamniyom Chanakarn, Kim Donghee, Noureddin Mazen, Singal Amit G, Wijarnpreecha Karn, Yang Ju Dong
Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi, China.
Hepatol Commun. 2025 Jan 7;9(1). doi: 10.1097/HC9.0000000000000629. eCollection 2025 Jan 1.
The incidence of cancer and the prevalence of metabolic disease and metabolic dysfunction-associated steatotic liver disease is increasing in young adults. However, updated global data on metabolic dysfunction-associated steatohepatitis (MASH)-associated primary liver cancer (PLC) in young adults remains scarce.
This study analyzed data from the Global Burden of Disease study between 2000 and 2021 to assess the age-standardized incidence, mortality, and disability-adjusted life years rates from MASH-associated PLC in young adults (15-49 y).
In 2021, there were 4300 incidence cases, 3550 deaths, and 179,340 disability-adjusted life years from MASH-associated PLC in young adults. Among various etiologies of PLC in young adults, only MASH-associated PLC had increased incidence rates (annual percent change: +0.26, 95% CI: 0.16%-0.35%), with the Eastern Mediterranean region having the largest observed increase (annual percent change: 1.46%, 95% CI: 1.40%-1.51%). In 2021, MASH-associated PLC in young adults made up 6% (+1% from 2000) incident cases, 6% (+2% from 2000) deaths, and 6% (+2% from 2000) disability-adjusted life years of all PLC in this age group. Over half of the countries exhibited an increase in age-standardized incidence rate from MASH-associated PLC in young adults from 2000 to 2021.
The incidence of MASH-associated PLC in young adults is significantly increasing, signaling likely future increases in PLC incidence among older adults as this cohort ages. This trend necessitates urgent strategies worldwide to mitigate the epidemics of MASH-associated PLC in young adults.
年轻人中癌症的发病率以及代谢性疾病和代谢功能障碍相关脂肪性肝病的患病率正在上升。然而，关于年轻人中代谢功能障碍相关脂肪性肝炎（MASH）相关原发性肝癌（PLC）的最新全球数据仍然稀缺。
本研究分析了2000年至2021年全球疾病负担研究的数据，以评估年轻人（15 - 49岁）中MASH相关PLC的年龄标准化发病率、死亡率和伤残调整生命年率。
2021年，年轻人中MASH相关PLC的发病病例有4300例，死亡3550例，伤残调整生命年为179340年。在年轻人PLC的各种病因中，只有MASH相关PLC的发病率有所上升（年变化率：+0.26，95%置信区间：0.16% - 0.35%），其中东地中海地区的上升幅度最大（年变化率：1.46%，95%置信区间：1.40% - 1.51%）。2021年，年轻人中MASH相关PLC占该年龄组所有PLC发病病例的6%（比2000年增加1%）、死亡病例的6%（比2000年增加2%）和伤残调整生命年的6%（比2000年增加2%）。超过一半的国家在2000年至2021年期间年轻人中MASH相关PLC的年龄标准化发病率有所上升。
年轻人中MASH相关PLC的发病率正在显著上升，这表明随着这一人群年龄增长，老年人中PLC发病率可能会在未来上升。这一趋势需要全球采取紧急策略来缓解年轻人中MASH相关PLC的流行。
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