Smith M J, Pihl R O, Farrell B
Neurobehav Toxicol Teratol. 1985 Jan-Feb;7(1):19-22.
The present study investigated the hypothesis that changes in the frequency of specific behaviors, not assessed by the traditionally employed global measures of locomotor activity, may occur following exposure to cadmium. Two groups of newborn male rat pups were treated orally with either 1.0 mg/kg CdCl2 for 14 days or 10.0 mg/kg CdCl2 for one day followed by 13 days of the treatment vehicle only. A control group received only the vehicle. At 50 days of age, animals were observed in their home cage for 12 hours and the amount of time spent engaged in each of eight separate categories of behavior was recorded. Subsequently, exploratory behavior in an open field was assessed. The single large dose of cadmium resulted in weight loss and a significantly slower growth rate significantly increased rearing in the home cage and significantly decreased inner square exploratory behavior in the open field. Implications of emotional hyporeactivity and physiological explanations which may account for the differences observed between the two treatment regimens are discussed.
接触镉后，特定行为的频率可能会发生变化，而这些变化无法通过传统使用的总体运动活动测量方法评估出来。两组新生雄性大鼠幼崽，一组口服1.0毫克/千克氯化镉，持续14天；另一组口服10.0毫克/千克氯化镉，持续1天，随后仅用赋形剂处理13天。对照组仅接受赋形剂。在动物50日龄时，将它们置于其饲养笼中观察12小时，并记录它们在八类不同行为中各自所花费的时间。随后，评估其在旷场中的探究行为。单次大剂量镉导致体重减轻和生长速率显著减慢，在家笼中显著增加竖尾次数，在旷场中显著减少内侧方格探究行为。本文讨论了情绪反应低下的影响以及可能解释两种处理方案间观察到差异的生理学解释。
