Ali M M, Murthy R C, Chandra S V
Neurobehav Toxicol Teratol. 1986 Sep-Oct;8(5):463-8.
The developmental and behavioral toxicity of gestational exposure to low levels of cadmium (Cd, 4.2 and 8.4 micrograms/ml in drinking water) were assessed in rats. Significant decreases in birth weight and growth rate were observed in the 8.4 micrograms Cd/ml group. The metal exposure had no effect on the ontogeny of physical landmarks, surface and air righting reflexes and visual placing, but a significant hyperactivity and delay in the development of cliff aversion and swimming behavior were observed in the neonatal pups of either treatment group. Marked decreases in the locomotor activity shuttle box performance were evident at 60 days but not at 90 days of postnatal life. The apomorphine-induced hyperactivity was not affected in these rats at either age. These data indicate that Cd exposure during the critical periods of development might result in developmental and behavioral deficits with longterm implications on adult behavior.
在大鼠中评估了孕期暴露于低水平镉（Cd，饮用水中浓度为4.2和8.4微克/毫升）的发育和行为毒性。在8.4微克Cd/毫升组中观察到出生体重和生长速率显著下降。金属暴露对身体标志的个体发生、表面和空中翻正反射以及视觉放置没有影响，但在两个治疗组的新生幼崽中均观察到明显的多动以及悬崖回避和游泳行为发育延迟。在出生后60天，穿梭箱运动活动表现明显下降，但在90天时没有下降。在这两个年龄段，阿扑吗啡诱导的多动在这些大鼠中均未受影响。这些数据表明，在发育的关键时期接触镉可能会导致发育和行为缺陷，对成年行为产生长期影响。
