关于针对恰加斯病的疫苗的最新情况。
An Update on Vaccines Against and Chagas Disease.
作者信息
Garg Nisha J
机构信息
Department of Microbiology & Immunology, University of Texas Medical Branch (UTMB), Galveston, TX 77555-1070, USA.
Institute for Human Infections and Immunity, University of Texas Medical Branch (UTMB), Galveston, TX 77555-1070, USA.
出版信息
Pathogens. 2025 Jan 30;14(2):124. doi: 10.3390/pathogens14020124.
Chagas disease (CD) is a global health concern, with no existing therapies to prophylactically treat adults traveling to endemic countries or those who may already be infected with . The economic burden of Chagas cardiomyopathy and heart failure, due to healthcare costs and lost productivity from premature deaths, provides a strong rationale for investment in the development of immune therapies against CD. Vaccine efficacy is proposed to depend heavily on the induction of a robust Th1 response for the clearance of intracellular pathogens like . In this review, updated information on the efforts for vaccine development against CD is provided.
恰加斯病（CD）是一个全球健康问题，对于前往流行国家的成年人或可能已经感染该病的人，目前没有预防性治疗方法。由于医疗费用以及过早死亡导致的生产力损失，恰加斯心肌病和心力衰竭带来的经济负担为投资开发针对CD的免疫疗法提供了有力依据。疫苗效力很大程度上被认为取决于诱导强大的Th1反应以清除像[病原体名称缺失]这样的细胞内病原体。在本综述中，提供了针对CD疫苗开发工作的最新信息。
Zotero 插件