Li Junhao, Liu Yuanxin, Wang Li, Liu Yaqun, Chen Min
Department of Chemistry, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, Wuhan 430070, China.
J Org Chem. 2025 Mar 7;90(9):3308-3321. doi: 10.1021/acs.joc.4c02942. Epub 2025 Feb 26.
Herein, we report a photocatalytic redox-neutral and reductive deoxygenative alkylation of -acyl carbamothioates from benzylic alcohols, with substituted Hantzsch esters and allylic sulfones to afford unsymmetrical 1,2-diaryl ethanes and allylarylmethanes, respectively. This protocol facilitates facile deoxyalkylation of primary, secondary, and tertiary benzylic alcohol-derived -acyl carbamothioates, which features mild reaction conditions, broad functional group tolerance, and the obviation of external S/O trapping reagents as well as transition metal-coupling catalysts.
在此，我们报道了一种光催化氧化还原中性且还原脱氧的烷基化反应，该反应利用苄醇、取代的汉斯酯和烯丙基砜对酰基氨基硫代甲酸酯进行反应，分别得到不对称的1,2 - 二芳基乙烷和烯丙基芳基甲烷。该方法促进了伯、仲和叔苄醇衍生的酰基氨基硫代甲酸酯的脱氧烷基化反应，具有反应条件温和、官能团耐受性广、无需外部硫/氧捕获试剂以及过渡金属偶联催化剂等特点。
