Morgan Michael J, Kim You-Sun
Department of Natural Sciences, Northeastern State University, Tahlequah, OK 74464, USA.
Department of Biochemistry, Ajou University School of Medicine, Ajou University, Suwon 16499, Korea; Department of Biomedical Sciences, Graduate School, Ajou University, Suwon 16499, Korea.
Mol Cells. 2025 May;48(5):100199. doi: 10.1016/j.mocell.2025.100199. Epub 2025 Feb 24.
Receptor-interacting protein kinase-3 is essential for the cell death pathway called necroptosis. Necroptosis is activated by the death receptor ligands and pattern recognition receptors of the innate immune system, leading to significant consequences in inflammation and in diseases, particularly cancer. Necroptosis is highly proinflammatory compared with other modes of cell death because cell membrane integrity is lost, resulting in releases of cytokines and damage-associated molecular patterns that potentiate inflammation and activate the immune system. We discuss various ways that necroptosis is triggered along with its potential role in cancer and therapy.
受体相互作用蛋白激酶-3对于称为坏死性凋亡的细胞死亡途径至关重要。坏死性凋亡由先天免疫系统的死亡受体配体和模式识别受体激活，在炎症和疾病（尤其是癌症）中会导致严重后果。与其他细胞死亡模式相比，坏死性凋亡具有高度促炎性，因为细胞膜完整性丧失，导致细胞因子释放和损伤相关分子模式，从而增强炎症并激活免疫系统。我们讨论了坏死性凋亡被触发的各种方式及其在癌症和治疗中的潜在作用。
