Mokbel Ramia, Kodresko Alevtina, Mokbel Kefah, Ghazal Heba, Trembley Jon, Jouhara Hussam
The Princess Grace Hospital, Part of HCA Healthcare UK, London, U.K.
Heat Pipe and Thermal Management Research Group, College of Engineering, Design and Physical Sciences, Brunel University, London, U.K.
In Vivo. 2025 Mar-Apr;39(2):577-612. doi: 10.21873/invivo.13865.
Skin and subcutaneous diseases represent a significant public health burden, profoundly impacting quality of life, social interactions, mental health, and daily activities-raising concerns worldwide. In modern cryogenics, cryosurgery is among the therapeutic approaches employed by healthcare professionals to address this broad and complex range of diseases. Over the past four decades, cryosurgery has evolved into a valuable treatment option, used alone or as an adjunct therapy, and is adaptable to the needs of various special populations. This approach offers distinct advantages over established treatments due to its safety, efficiency, feasibility, and cost-effectiveness. However, a comprehensive, up-to-date review of cryosurgery's applications is lacking, which limits research dissemination and recognition among dermatologists. This review aims to provide an overview of cryosurgery principles and its current clinical practice in dermatology, covering a broad range of benign, premalignant, and malignant cutaneous conditions, and highlighting its potential as an essential approach in global healthcare.
皮肤和皮下疾病构成了重大的公共卫生负担，对生活质量、社交互动、心理健康和日常活动产生深远影响，引发了全球范围内的关注。在现代低温学中，冷冻手术是医疗专业人员用于治疗这类广泛而复杂疾病的治疗方法之一。在过去的四十年里，冷冻手术已发展成为一种有价值的治疗选择，可单独使用或作为辅助治疗，并且能够适应各种特殊人群的需求。由于其安全性、有效性、可行性和成本效益，这种方法相对于既定治疗方法具有明显优势。然而，目前缺乏对冷冻手术应用的全面、最新综述，这限制了皮肤科医生之间的研究传播和认知。本综述旨在概述冷冻手术的原理及其在皮肤科的当前临床实践，涵盖广泛的良性、癌前和恶性皮肤疾病，并强调其作为全球医疗保健重要方法的潜力。
