Wu Meng-Che, Li Yun-Feng, Lin Chen-Yu, Lin Nung-Hsiang, Lee Chien-Ying, Su Yu-Jung, Chang Hui-Chin, Gau Shuo-Yan
Division of Pediatric Gastroenterology, Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan, R.O.C.
In Vivo. 2025 Mar-Apr;39(2):1067-1077. doi: 10.21873/invivo.13911.
BACKGROUND/AIM: Hidradenitis suppurativa (HS) may be linked to an elevated risk of bipolar disorder, though the precise mechanism remains unclear. This study investigated the likelihood of bipolar disorder in patients with HS.
We analyzed the electronic health records of 60,850 patients with HS and 60,850 matched controls from the TriNetX network, excluding those with a prior bipolar disorder diagnosis. Propensity score matching was conducted (1:1 ratio), and hazard ratios (HRs) were calculated to assess the risk of new-onset bipolar disorder in patients with HS compared to controls.
After matching, the HR for developing bipolar disorder in patients with HS was 1.549 [95% confidence interval (CI)=1.270-1.889] after a 1-year follow-up, remaining significant in 3- and 5-year follow-ups and sensitivity analyses. Stratified by sex, female patients with HS showed a notably higher risk (HR=1.509, 95%CI=1.353-1.683), while no significant increase was seen in males.
Patients with HS have a significantly elevated risk of developing bipolar disorder, especially among females. Healthcare providers should be mindful of this association when treating patients with HS.
背景/目的：化脓性汗腺炎（HS）可能与双相情感障碍风险升高有关，但其确切机制尚不清楚。本研究调查了HS患者患双相情感障碍的可能性。
我们分析了来自TriNetX网络的60850例HS患者和60850例匹配对照的电子健康记录，排除了既往有双相情感障碍诊断的患者。进行倾向评分匹配（1:1比例），并计算风险比（HR）以评估HS患者与对照相比新发双相情感障碍的风险。
匹配后，HS患者在1年随访后患双相情感障碍的HR为1.549[95%置信区间（CI）=1.270-1.889]，在3年和5年随访及敏感性分析中仍具有显著性。按性别分层，女性HS患者显示出明显更高的风险（HR=1.509，95%CI=1.353-1.683），而男性未见显著增加。
HS患者患双相情感障碍的风险显著升高，尤其是女性。医疗服务提供者在治疗HS患者时应注意这种关联。
