Sandarage Ryan, Nashed Joseph Y, Tsai Eve C
Division of Neurosurgery, Department of Surgery, Faculty of Medicine, University of Ottawa, Ottawa.
Faculty of Medicine, Queen's University, Kingston.
Curr Opin Crit Care. 2025 Apr 1;31(2):117-122. doi: 10.1097/MCC.0000000000001245. Epub 2025 Feb 27.
The concept of 'time is spine' emphasizes early or ultra-early surgical decompression within 24 or 12 h, respectively, after spinal cord injury (SCI) to maximize recovery. This review updates the latest findings on the timing of surgical decompression and hemodynamic management in acute SCI, focusing on neurological outcomes and complications.
While early decompression may improve neurological outcomes, factors like injury severity, comorbidities, and system resources affect surgical timing. Recent studies question the benefits of ultra-early decompression, finding no significant improvement at 12 months, suggesting earlier analyses may have overstated its benefits. Current recommendations include tailoring decompression timing to individual cases, considering patient-specific and systemic factors. New techniques like spinal cord pressure monitoring, intraoperative ultrasound, and advanced imaging are advancing targeted intervention and hemodynamic management in SCI.
The timing of spinal decompression and hemodynamic management may impact neurological function, however, because of the deficiencies of current studies, individualized, patient-tailored decision-making is critical. A multidisciplinary approach that considers injury severity and patient characteristics is essential for optimal management. Further research is required to refine the timing of surgical intervention and explore additional factors influencing recovery.
“时间就是脊柱”这一概念强调在脊髓损伤(SCI)后分别于24小时或12小时内进行早期或超早期手术减压,以实现恢复最大化。本综述更新了急性SCI手术减压时机和血流动力学管理的最新研究结果,重点关注神经学转归和并发症。
虽然早期减压可能改善神经学转归,但损伤严重程度、合并症和系统资源等因素会影响手术时机。近期研究对超早期减压的益处提出质疑,发现在12个月时并无显著改善,这表明早期分析可能夸大了其益处。当前建议包括根据个体情况调整减压时机,考虑患者特异性和系统性因素。脊髓压力监测、术中超声和先进成像等新技术正在推动SCI的靶向干预和血流动力学管理。
脊柱减压和血流动力学管理的时机可能影响神经功能,然而,由于当前研究存在不足,个体化、针对患者的决策至关重要。采用多学科方法并考虑损伤严重程度和患者特征对于优化管理至关重要。需要进一步研究以完善手术干预时机并探索影响恢复的其他因素。