Ramachandran Hema, Anis Siti Nor Syairah, Ansari Nor Faezah, Sevakumaran Vigneswari, Arifshah Nurhanani, Rufadzil Nurul Afifah Mohd Kamal, Annuar Mohamad Suffian Mohamad, Al-Ashraf Abdullah Amirul
School of Biological Sciences, Faculty of Integrated Life Sciences, Quest International University Perak, 30250, Ipoh, Perak, Malaysia.
School of Biological Sciences, Universiti Sains Malaysia, 11800, Gelugor, Penang, Malaysia.
Arch Microbiol. 2025 Feb 27;207(4):72. doi: 10.1007/s00203-025-04256-9.
Plastic waste pollution is escalating globally at an unprecedented pace, with a significant measure of this waste remaining unrecycled. Hence, polyhydroxyalkanoates (PHAs), a biogenic polyester, as a potential alternative to synthetic plastics has been intensively studied over the years. PHAs are biodegradable and biocompatible polyester produced by various microorganisms through the bioprocessing of sustainable sources. Bacterial PHAs show potential as an eco-friendly, biodegradable, and biocompatible alternative to conventional plastics. Malaysian environment, anthropogenic and natural, harbors an enormous diversity of microorganisms as well as various bacteria that produce PHAs. Hence, the current submission highlights on four indigenous PHA producers, isolated from the local environments, namely Cupriavidus malaysiensis USMAA2-4, Cupriavidus malaysiensis USMAA10-20, Cupriavidus malaysiensis USMAHM13, and Pseudomonas putida BET001. The four strains have contributed significantly as a workhorse in advancing PHA research and innovation in Malaysia and globally. Their uniqueness and significance in the PHA investigation, which include biosynthesis, recovery strategies, metabolic pathways involved, characteristics and properties of extracted PHA, biodegradation, and its potential applications are discussed.
塑料垃圾污染正在全球以前所未有的速度升级，其中很大一部分垃圾仍未回收利用。因此，聚羟基脂肪酸酯（PHA），一种生物源聚酯，作为合成塑料的潜在替代品，多年来一直受到深入研究。PHA是由各种微生物通过可持续来源的生物加工生产的可生物降解且生物相容的聚酯。细菌PHA作为一种环保、可生物降解且生物相容的传统塑料替代品显示出潜力。马来西亚的环境，包括人为和自然环境，蕴藏着极其多样的微生物以及各种产生PHA的细菌。因此，本论文重点介绍了从当地环境中分离出的四种本土PHA生产者，即马来西亚贪铜菌USMAA2 - 4、马来西亚贪铜菌USMAA10 - 20、马来西亚贪铜菌USMAHM13和恶臭假单胞菌BET001。这四株菌株在推动马来西亚乃至全球的PHA研究与创新方面发挥了重要作用。本文讨论了它们在PHA研究中的独特性和重要性，包括生物合成、回收策略、涉及的代谢途径、提取的PHA的特性和性能、生物降解及其潜在应用。
