Petrovic Sabrina, Beovic Bojana, Tomic Viktorija, Bitenc Marko, Malovrh Mateja Marc, Dimitric Vladimir, Luznik Dane, Miklavcic Martina, Bozic Tamara, Gabrovec Tina, Sadikov Aleksander, Rozman Ales
1Surgery Bitenc, Medical Centre Ljubljana (MCL), Ljubljana, Slovenia.
2Clinic for Infectious Diseases and Fever Conditions, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Radiol Oncol. 2025 Feb 27;59(1):147-152. doi: 10.2478/raon-2025-0018. eCollection 2025 Mar 1.
Postoperative pneumonia (POP) remains a leading cause of mortality following lung surgery. Recent studies have confirmed that the respiratory tract below the vocal cords is not sterile and often harbours potentially pathogenic microorganisms (PPMs), putting patients with lung malignancies at an increased risk for pulmonary infections.
The study analysed 149 patients who underwent bronchoscopy for lung lesions suspected to be lung cancer. Protected specimen brush (PSB) samples were obtained during bronchoscopy prior to any specific treatment. Bacterial identification and antimicrobial susceptibility testing were conducted on the isolated strains.
Bacterial colonization was detected in 88.6% of patients, with 21.5% carrying PPMs. Notably, patients with type 2 diabetes exhibited a higher rate of PPM colonization compared to others. Antibiotic susceptibility testing showed no significant differences in efficacy between amoxicillin with clavulanic acid and first-generation cephalosporin in both colonized patients and those with PPMs. Importantly, no multidrug-resistant bacteria were identified.
Our findings indicate a slightly lower PPM colonization rate compared to previous studies, possibly due to the unique geographic characteristics of the study population. The absence of significant differences in bacterial susceptibility between the two tested antibiotics highlights the need for further research to refine perioperative infection management strategies.
术后肺炎（POP）仍然是肺手术后死亡的主要原因。最近的研究证实，声带以下的呼吸道并非无菌，常常携带潜在致病微生物（PPM），这使得肺部恶性肿瘤患者发生肺部感染的风险增加。
本研究分析了149例因疑似肺癌的肺部病变而接受支气管镜检查的患者。在进行任何特异性治疗之前，于支气管镜检查期间获取保护性标本刷（PSB）样本。对分离出的菌株进行细菌鉴定和药敏试验。
在88.6%的患者中检测到细菌定植，其中21.5%携带PPM。值得注意的是，2型糖尿病患者的PPM定植率高于其他患者。药敏试验表明，在定植患者和携带PPM的患者中，阿莫西林克拉维酸与第一代头孢菌素之间的疗效无显著差异。重要的是，未鉴定出多重耐药菌。
我们的研究结果表明，与之前的研究相比，PPM定植率略低，这可能归因于研究人群独特的地理特征。两种受试抗生素之间细菌敏感性无显著差异，这凸显了进一步开展研究以完善围手术期感染管理策略的必要性。
