Hu Shuhui, Dalbeth Nicola, Li Zhiqiang, Chen Ying, Dong Bingzi, Wang Can, Sun Wenyan, Li Changgui, Lu Jie
Shandong Provincial Clinical Research Center for Immune Diseases, the Affiliated Hospital of Qingdao University, 266003 Qingdao, China; Department of Endocrinology and Metabolism, the Affiliated Hospital of Qingdao University, 266003 Qingdao, China.
Department of Medicine, University of Auckland, 1023 Auckland, New Zealand.
Joint Bone Spine. 2025 Jul;92(4):105876. doi: 10.1016/j.jbspin.2025.105876. Epub 2025 Feb 25.
Gout in young people is increasingly common across the world, including in China. This study aimed to identify clinical and genetic associations with early-onset gout in Chinese men.
One thousand two hundred and one Chinese men with gout were included. Early-onset gout was defined as the first presentation of gout at <30years. Twenty single nucleotide polymorphisms (SNPs) identified as gout-risk loci or associated with serum urate (SU) levels in East Asian populations were genotyped. Logistic regression was used to evaluate the association of SNPs and clinical factors with early-onset gout.
Four hundred and thirty-three (36.1%) participants were identified as having early-onset gout. These patients had higher SU levels and were more likely to experience gout flares than those with later-onset gout. The ALDH2 rs671 GG genotype was associated with a lower risk of early-onset gout. Compared to those with GG genotype who never drank alcohol before gout onset, individuals with AA or AG genotypes who drank alcohol before gout onset had a higher likelihood of early-onset gout. Additionally, alcohol intake significantly increased the likelihood of gout flares in early-onset gout patients. Moreover, body mass index, sugar-sweetened beverage intake, family history of gout and renal urate underexcretion were associated with early-onset gout.
The ALDH2 rs671 GG genotype was significantly associated with a lower risk of early-onset gout, while individuals with the AA or AG genotype who consumed alcohol were more susceptible. These findings indicate that alcohol intake is a potentially modifiable risk factor for early-onset gout in genetically susceptible individuals.
痛风在全球范围内，包括在中国，在年轻人中越来越普遍。本研究旨在确定中国男性早发性痛风的临床和遗传关联。
纳入1201名患有痛风的中国男性。早发性痛风定义为痛风首次发作年龄<30岁。对20个在东亚人群中被鉴定为痛风风险位点或与血清尿酸（SU）水平相关的单核苷酸多态性（SNP）进行基因分型。采用逻辑回归评估SNP和临床因素与早发性痛风的关联。
433名（36.1%）参与者被确定为患有早发性痛风。这些患者的SU水平较高，且比晚发性痛风患者更易出现痛风发作。ALDH2 rs671 GG基因型与早发性痛风风险较低相关。与痛风发作前从不饮酒的GG基因型个体相比，痛风发作前饮酒的AA或AG基因型个体患早发性痛风的可能性更高。此外，饮酒显著增加了早发性痛风患者痛风发作的可能性。此外，体重指数、含糖饮料摄入量、痛风家族史和肾脏尿酸排泄不足与早发性痛风有关。
ALDH2 rs671 GG基因型与早发性痛风风险较低显著相关，而饮酒的AA或AG基因型个体更易患病。这些发现表明，饮酒是遗传易感个体早发性痛风的一个潜在可改变的风险因素。
