细胞外囊泡运输gasdermin孔道，放大炎症性细胞死亡。
Extracellular vesicles transport gasdermin pores, amplifying inflammatory cell death.
作者信息
Sharma Bhesh Raj, Kanneganti Thirumala-Devi
机构信息
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
出版信息
Trends Immunol. 2025 Mar;46(3):183-185. doi: 10.1016/j.it.2025.02.004. Epub 2025 Feb 26.
Abstract
Lytic cell death is crucial for antimicrobial and antitumor immunity; however, unchecked pyroptosis drives pathology in sepsis. Wright et al. demonstrate that widespread cell death following pyroptosis is propagated by extracellular vesicles (EVs) carrying gasdermin D (GSDMD) pores that become integrated into the membrane of neighboring cells, driving inflammatory cell death.
摘要
细胞溶解性死亡对抗菌和抗肿瘤免疫至关重要；然而，不受控制的细胞焦亡会引发脓毒症的病理过程。赖特等人证明，细胞焦亡后广泛的细胞死亡是由携带gasdermin D（GSDMD）孔的细胞外囊泡（EVs）传播的，这些孔会整合到邻近细胞的膜中，导致炎性细胞死亡。
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本文引用的文献
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