Subramaniyan Vetriselvan, Hanim Yusoff Umul
Pharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500, Subang Jaya, Selangor, Malaysia.
Division of Pharmacology, School of Medical and Life Sciences, Sunway University, Sunway, 47500, Malaysia.
Int J Obes (Lond). 2025 Mar;49(3):492-506. doi: 10.1038/s41366-025-01729-1. Epub 2025 Feb 27.
The worldwide health emergency of obesity is closely connected to how dietary fats are metabolized, whereas the process is significantly influenced by pancreatic lipase (PL), an enzyme critical for lipid hydrolysis into fatty acids. This narrative review employs a methodological approach utilizing literature searches of PubMed data up to March 2024. The search term criteria encompasses keywords related to the role, mechanism, challenges, and current and future treatments of pancreatic lipase in obesity with an overall references is 106. This paper offers a comprehensive explanation of the role of PL, underlining its significance in the digestive process and lipid imbalances that contribute to obesity and by extension, its impact on obesity development and progression. Additionally, it delves into the dual functionality of the pancreas, emphasizing its impact on metabolism and energy utilization which, when dysregulated, promotes obesity. A focal point of this review is the investigation into the efficacy, challenges, and adverse effects of current pancreatic lipase inhibitors, with orlistat being highlighted as a primary current drug delivery. By discussing advanced obesity treatments, including the exploration of novel anti-obesity medications that target specific biological pathways, this review underscores the complexity of obesity treatment and the necessity for a multifaceted approach. In conclusion, this paper emphasizing the importance of understanding the role of enzymes like pancreatic lipase mechanistic and adopting a multidisciplinary approach to treatment and side effects of current obesity drugs and explore new emerging therapeutic strategies for more effective obesity management.
肥胖这一全球健康紧急状况与膳食脂肪的代谢方式密切相关，而这一过程受到胰脂肪酶（PL）的显著影响，胰脂肪酶是一种对脂质水解为脂肪酸至关重要的酶。本叙述性综述采用了一种方法，利用截至2024年3月的PubMed数据进行文献检索。检索词标准包括与胰脂肪酶在肥胖中的作用、机制、挑战以及当前和未来治疗方法相关的关键词，参考文献总数为106篇。本文全面解释了PL的作用，强调了其在消化过程和导致肥胖的脂质失衡中的重要性，进而阐述了其对肥胖发展和进展的影响。此外，还深入探讨了胰腺的双重功能，强调其对代谢和能量利用的影响，当这种调节失调时会促进肥胖。本综述的一个重点是研究当前胰脂肪酶抑制剂的疗效、挑战和不良反应，奥利司他被突出作为主要的当前药物。通过讨论先进的肥胖治疗方法，包括探索针对特定生物途径的新型抗肥胖药物，本综述强调了肥胖治疗的复杂性以及采取多方面方法的必要性。总之，本文强调了理解胰脂肪酶等酶的作用机制以及采用多学科方法治疗当前肥胖药物的副作用并探索新出现的治疗策略以更有效地管理肥胖的重要性。
