Fazlollahpour-Naghibi Andarz, Taha Seyed Reza, Shariatzadeh Mahdieh, Daneshdoust Danyal, Bagheri Kimia, Farkhondeh Tahereh, Samini Mohammad, Pourhanifeh Mohammad Hossein, Samarghandian Saeed
Faculty of Medicine, Islamic Azad University, Sari Branch, Sari, Iran.
Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Curr Cancer Drug Targets. 2025 Feb 27. doi: 10.2174/0115680096329727250129173510.
Cutaneous melanoma, one of the most fatal and aggressive types of skin cancer, is a malignant tumor created from pigment-producing cells called melanocytes. The mor-bidity and incidence rate of melanoma are increasing around the world. Considering all developments in diagnostic and therapeutic approaches, early diagnosis and more effective targeted therapies are still urgent for melanoma. Non-coding RNAs (ncRNAs), including microRNAs and long non-coding RNAs, are key role players in fundamental cellular pro-cesses and have various biological properties. It has been demonstrated that the dysregula-tion of these biomarkers contributes to melanoma pathogenesis. Furthermore, programmed cell death (PCD), as an important cellular event, has been shown to play a role in the initi-ation and progression of cutaneous melanoma. Recent investigations have reported that the interplay between ncRNAs and PCD can be considered a novel choice for targeted therapy in melanoma. Thus, this review discusses PCD-related ncRNAs in melanoma, focusing on underlying pathways.
皮肤黑色素瘤是最致命且侵袭性最强的皮肤癌类型之一，是一种由称为黑素细胞的色素生成细胞产生的恶性肿瘤。黑色素瘤的发病率和发生率在全球范围内都在上升。考虑到诊断和治疗方法的所有进展，黑色素瘤的早期诊断和更有效的靶向治疗仍然迫在眉睫。非编码RNA（ncRNA），包括微小RNA和长链非编码RNA，是基本细胞过程中的关键角色，具有多种生物学特性。已经证明，这些生物标志物的失调促成了黑色素瘤的发病机制。此外，程序性细胞死亡（PCD）作为一个重要的细胞事件，已被证明在皮肤黑色素瘤的发生和发展中起作用。最近的研究报告称，ncRNA与PCD之间的相互作用可被视为黑色素瘤靶向治疗的新选择。因此，本综述讨论了黑色素瘤中与PCD相关的ncRNA，重点关注潜在途径。
