Larsen Birgitte Carbuhn, Harmsen Martin Christian, Vase Henrik, Nielsen-Kudsk Jens Erik, Andersen Asger
Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Department of Internal Medicine, Regional Hospital Randers, Randers, Denmark.
Struct Heart. 2024 Oct 24;9(1):100375. doi: 10.1016/j.shj.2024.100375. eCollection 2025 Jan.
A patent foramen ovale (PFO) has a complex anatomy, and evaluating the size before closure may be challenging. We aimed to investigate the correlation between preprocedural transesophageal echocardiography (TEE) and balloon sizing of PFO in patients undergoing percutaneous PFO closure.
A retrospective single-center study with analysis of 100 patients who, due to paradox thromboembolism in the left circulation, underwent percutaneous PFO closure. The PFO sizing was compared to measures attained by TEE and balloon sizing using linear regression analysis.
PFO size measured by TEE occurred smaller than balloon sizing (2.19 mm [95% CI: 1.91 to 2.46] vs. 8.51 mm [95% CI: 8.02 to 9.00], < 0.001). Additionally, neither the PFO channel length nor the atrial septal mobility measured by TEE correlated to the PFO size attained by balloon sizing, respectively (slope 0.018 [95% CI: 0.117 to 0.081], R = 0.036, = 0.719) and (slope 0.049 [95% CI: ?0.043 to 0.141], R = 0.105, = 0.297). Statistically significant difference in regression analysis but poor correlation was found between both TEE attained PFO and shunt size when compared to balloon sizing. Diverting patients according to the size of the PFO shunt was not statistically significant between PFO of moderate size compared, respectively, to a large and small PFO size. However, a difference was observed between a small and large PFO shunt size.
PFO defect and shunt size measured by TEE showed a poor correlation with balloon sizing. Neither PFO channel length nor septal mobility were correlated to the PFO size measured by balloon sizing.
卵圆孔未闭（PFO）具有复杂的解剖结构，在封堵前评估其大小可能具有挑战性。我们旨在研究经皮PFO封堵患者术前经食管超声心动图（TEE）与PFO球囊测量大小之间的相关性。
一项回顾性单中心研究，分析了100例因左循环矛盾性血栓栓塞而接受经皮PFO封堵的患者。使用线性回归分析将PFO大小与通过TEE和球囊测量获得的结果进行比较。
TEE测量的PFO大小小于球囊测量值（2.19 mm [95% CI：1.91至2.46] 对比 8.51 mm [95% CI：8.02至9.00]，P < 0.001）。此外，TEE测量的PFO通道长度和房间隔活动度均分别与球囊测量获得的PFO大小无关（斜率0.018 [95% CI：0.117至0.081]，R = 0.036，P = 0.719）以及（斜率0.049 [95% CI：−0.043至0.141]，R = 0.105，P = 0.297）。与球囊测量相比，TEE获得的PFO和分流大小之间在回归分析中有统计学显著差异，但相关性较差。根据PFO分流大小对患者进行分类，中等大小PFO与大、小PFO大小相比，差异无统计学意义。然而，小PFO和大PFO分流大小之间存在差异。
TEE测量的PFO缺损和分流大小与球囊测量结果相关性较差。PFO通道长度和间隔活动度均与球囊测量的PFO大小无关。
