Mierzejewski T, Słowikowska B, Wasilewska B
Pol Arch Weter. 1979;22(1):117-23.
On dogs under Eunarkon anesthesia (0,03 ml Eunarkon/kg body weight) after one intramuscular lethal injection of phoschlor (500 mg/lg body weight = LD100) the proteolytic activity (APR) was estimated in the blood plasma at pH 3,5-APR-3,5 and in the hemolyzed blood at pH-7,4-APR-7,4. The results showed that heavy poisoning with phoschlor led to metabolic disturbances in the proteolytic system of the blood plasma and blood, the expression of which was increasing in the course of time a statistically important increase (alpha = 0,001) of APR-3,5 and APR-7,4. APR induction in blood is not a result of direct activation of enzymes by pesticides. It takes place outside the circulation system.
在使用尤那康麻醉（0.03毫升尤那康/千克体重）的犬只身上，经肌肉注射一次致死剂量的保棉磷（500毫克/千克体重=LD100）后，测定血浆在pH 3.5时的蛋白水解活性（APR-3.5）以及溶血血液在pH 7.4时的蛋白水解活性（APR-7.4）。结果表明，保棉磷重度中毒导致血浆和血液蛋白水解系统的代谢紊乱，其表现为随着时间推移，APR-3.5和APR-7.4有统计学意义的显著增加（α=0.001）。血液中APR的诱导并非农药直接激活酶的结果。它发生在循环系统之外。
