Zafar Farjad, Riaz Maryam, Ahmed Rafay, Kumar Rahul
Department of Dental Implantology, Baqai Dental College, Baqai Medical University, Karachi, Pakistan.
Department of Oral Biology, Baqai Dental College, Baqai Medical University, Karachi, Pakistan.
J Indian Soc Periodontol. 2024 Jul-Aug;28(4):417-426. doi: 10.4103/jisp.jisp_429_23. Epub 2025 Jan 6.
This systematic review aims to comprehensively assess the efficacy of soft-tissue augmentation procedures in enhancing the width of keratinized mucosa (KM) surrounding implants with compromised soft-tissue status.
A thorough search was conducted on MEDLINE through PubMed and EMBASE via Ovid, supplemented by manual article searches. Inclusion criteria comprised human studies published in English within the past decade (up to July 2023), focusing on soft-tissue grafting techniques for augmenting keratinized mucosal width. The Joanna Briggs Institute critical appraisal tools were employed to evaluate the risk of bias in selected studies.
The review includes 27 studies, comprising nine prospective clinical studies, 13 randomized controlled trials (RCTs), and 5 case series. Notably, interventions demonstrated an augmented KM ranging from 0.89 mm to 7.7 mm. Optimal outcomes were observed with apically positioned partial-thickness flaps and vestibuloplasty (VP) utilizing xenogeneic collagen matrix (XCM) or free gingival graft (FGG). However, heterogeneity in study designs precluded meta-analysis.
Despite the limitations, this study emphasizes the potential to augment KM width through apically positioned partial-thickness flaps and VP techniques employing XCM or FGG. Further RCTs with extended follow-up are needed to refine treatment approaches, improve outcomes, and address gaps in understanding graft integration mechanisms and strategies to minimize graft shrinkage.
本系统评价旨在全面评估软组织增量手术在增加软组织状况不佳的种植体周围角化黏膜(KM)宽度方面的疗效。
通过PubMed在MEDLINE以及通过Ovid在EMBASE上进行了全面检索,并辅以手工文献检索。纳入标准包括过去十年(截至2023年7月)以英文发表的人体研究,重点是用于增加角化黏膜宽度的软组织移植技术。采用乔安娜·布里格斯研究所的批判性评估工具来评估所选研究中的偏倚风险。
该评价纳入了27项研究,包括9项前瞻性临床研究、13项随机对照试验(RCT)和5个病例系列。值得注意的是,干预措施使KM增加了0.89毫米至7.7毫米。采用异种胶原基质(XCM)或游离龈移植(FGG)的根尖定位部分厚度瓣和前庭成形术(VP)观察到了最佳效果。然而,研究设计的异质性妨碍了荟萃分析。
尽管存在局限性,但本研究强调了通过采用XCM或FGG的根尖定位部分厚度瓣和VP技术增加KM宽度的潜力。需要进一步开展随访时间更长的RCT,以完善治疗方法、改善治疗效果,并解决在移植物整合机制理解和尽量减少移植物收缩策略方面的差距。