甲状腺功能障碍与腕管综合征之间的因果关系：一项孟德尔随机化研究。
The causal relationship between thyroid dysfunction and carpal tunnel syndrome: A Mendelian randomization study.
作者信息
Zhang Fan, Cui Rongrong, Yin Liang, Bi Rongxiu, Xu Honghao, Wang Shilu
机构信息
Shandong Traditional Chinese Medicine University, Jinan, China.
Affiliated Hospital of Shandong University of Traditional, Jinan, China.
出版信息
Medicine (Baltimore). 2025 Feb 28;104(9):e41648. doi: 10.1097/MD.0000000000041648.
Mendelian randomization was used to investigate the causal relationship between thyroid dysfunction (including hypothyroidism and hyperthyroidism) and carpal tunnel syndrome. Genetic loci independently associated with hypothyroidism and hyperthyroidism were selected as instrumental variables from pooled data from genome-wide association studies. Inverse variance weighting (IVW) was used to analyze the causal effect, supplemented by weighted median and MR-Egger. Heterogeneity test, pleiotropy testing and leave-one-out analysis were used to analyze the sensitivity test to explore the robustness of the results. Both hypothyroidism and hyperthyroidism increase the risk of carpal tunnel syndrome (hypothyroidism: IVW, OR = 1.04, 95% CI = 1.01-1.08, P = .017; hyperthyroidism: IVW, OR = 1.08, 95% CI = 1.05-1.12, P = 9.218E-06, no pleiotropy was found in both tests. Patients with thyroid dysfunction have an increased risk of carpal tunnel syndrome.
采用孟德尔随机化方法研究甲状腺功能障碍（包括甲状腺功能减退和甲状腺功能亢进）与腕管综合征之间的因果关系。从全基因组关联研究的汇总数据中选择与甲状腺功能减退和甲状腺功能亢进独立相关的基因位点作为工具变量。采用逆方差加权法（IVW）分析因果效应，并辅以加权中位数法和MR-Egger法。使用异质性检验、多效性检验和留一法分析进行敏感性检验，以探讨结果的稳健性。甲状腺功能减退和甲状腺功能亢进均会增加腕管综合征的风险（甲状腺功能减退：IVW，OR = 1.04，95%CI = 1.01-1.08，P = 0.017；甲状腺功能亢进：IVW，OR = 1.08，95%CI = 1.05-1.12，P = 9.218E-06，两项检验均未发现多效性）。甲状腺功能障碍患者患腕管综合征的风险增加。
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