Zhou Yue, Sun YuJian, Pan YuFan, Dai Yu, Xiao Yi, Yu YuFeng
College of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
College of Nursing, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
J Affect Disord. 2025 Jun 1;378:109-118. doi: 10.1016/j.jad.2025.02.080. Epub 2025 Feb 26.
Weekend catch-up sleep (WCS) may alleviate weekday sleep deprivation, but its relationship with depression risk remains unclear. This systematic review and meta-analysis aims to explore the association between WCS and depression risk.
A comprehensive search was conducted in PubMed, Cochrane Library, Embase, Web of Science, and Scopus for observational studies published up to June 1, 2024. Data extraction and bias assessment were independently performed by two reviewers. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated, with model selection based on the I statistic. Sensitivity analyses and publication bias tests were also conducted.
A total of ten cross-sectional studies (326,871 participants) were included. Meta-analysis showed that WCS was significantly associated with a reduced risk of depression (OR = 0.80, 95 % CI: 0.68-0.90). Subgroup analyses showed moderate amounts of WCS (0-2 h) may be protective, but WCS beyond 2 h had limited protective effects against depression. Qualitative analyses showed that the protective effect of WCS against depression was more pronounced in men and middle-aged adults, and was particularly applicable to those who were sleep-deprived on weekdays.
The cross-sectional design of included studies limits causality inference, and the sample primarily represents populations from the United States and South Korea, potentially affecting generalizability.
Moderate WCS is associated with lower depression risk in those with weekday sleep deficits, while excessive WCS may have diminishing or adverse effects. Further research should examine optimal WCS duration and underlying mechanisms.
周末补觉（WCS）可能缓解工作日的睡眠剥夺，但它与抑郁风险之间的关系仍不明确。本系统评价和荟萃分析旨在探讨WCS与抑郁风险之间的关联。
在PubMed、Cochrane图书馆、Embase、科学网和Scopus中进行全面检索，以查找截至2024年6月1日发表的观察性研究。由两名 reviewers 独立进行数据提取和偏倚评估。计算比值比（OR）和95%置信区间（CI），并根据I统计量进行模型选择。还进行了敏感性分析和发表偏倚检验。
共纳入10项横断面研究（326,871名参与者）。荟萃分析表明，WCS与抑郁风险降低显著相关（OR = 0.80，95%CI：0.68 - 0.90）。亚组分析表明，适量的WCS（0 - 2小时）可能具有保护作用，但超过2小时的WCS对抑郁的保护作用有限。定性分析表明，WCS对抑郁的保护作用在男性和中年成年人中更为明显，尤其适用于那些工作日睡眠不足的人。
纳入研究的横断面设计限制了因果推断，且样本主要代表来自美国和韩国的人群，可能影响普遍性。
适度的WCS与工作日睡眠不足者的较低抑郁风险相关，而过度的WCS可能产生递减或不利影响。进一步的研究应探讨最佳的WCS持续时间和潜在机制。
