[Various characteristics of the urinary excretion of glycosaminoglycans in patients with peptic ulcer, chronic duodenal ulcer and in their relatives].

The authors describe the results of studying secretion of glycosaminoglycans (GAG) with urine in 82 patients with peptic ulcer, 30 relatives and in 30 normal subjects with nonaggravated heredity. Patients with chronic duodenal ulcer during exacerbation and their normal relatives showed an essential reduction in the magnitude of the above indicator (1.6- and 1.8-fold, respectively, P less than 0.001) at the expense of a decrease in secretion of chondroitinsulfates (CDS) (2.4- and 2.1-fold, respectively, P less than 0.001). In peptic ulcer of the stomach, such a phenomenon was not recorded. During a disease remission there was an increase in GAG secretion with urine, linked with hyperheparinuria (13.1-fold, P less than 0.001). The data obtained indicate that the genetically determined impairment of CDS synthesis may be among one of the mechanisms by which hereditary aggravation in peptic ulcer of the duodenum is mediated. Hyperproduction of heparin during a disease remission is likely to play the role of one of the components of the defense-adaptation reaction responsible for ulcer healing.