Isaev M N, Rabinovich P D
Vopr Med Khim. 1988 Jan-Feb;34(1):62-5.
Excretion of individual glycosaminoglycans (GAG's) with urine was studied in patients with chronic duodenal ulcer. 31 patient with acute manifestations of the duodenal ulcer, 24 patients within the period of remission as well as 29 practically healthy persons were studied. Column chromatography on cellulose was used for separation of a mixture containing keratan sulfate, hyaluronic acid, heparan sulfate, chondroitin-4 and -6-sulfates, dermatan sulfate and heparin. During the acute period of duodenal ulcer daily excretion of all the individual GAG's with urine was decreased (especially distinct for the fraction of chondroitin-6-sulfate) as compared with excretion of these carbohydrates in healthy persons. The level of GAG excretion was increased distinctly, exceeding the values found in healthy persons, during the remission. Excretion of chondroitin-6-sulfate and keratan sulfate was markedly increased in these cases.
对患有慢性十二指肠溃疡的患者尿液中各糖胺聚糖（GAG）的排泄情况进行了研究。研究对象包括31例十二指肠溃疡急性发作患者、24例缓解期患者以及29例实际健康的人。采用纤维素柱色谱法分离包含硫酸角质素、透明质酸、硫酸乙酰肝素、硫酸软骨素-4和-6、硫酸皮肤素及肝素的混合物。与健康人相比，十二指肠溃疡急性期所有个体GAG的每日尿排泄量均降低（硫酸软骨素-6部分尤为明显）。缓解期GAG排泄水平明显升高，超过健康人水平。此期间硫酸软骨素-6和硫酸角质素的排泄显著增加。
