Han Wei, He Yue, Shao YuanWei, Sibomana Pacifique, Yang Yi, Yu Ming
Department of Neurology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Department of Radiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
Brain Behav. 2025 Mar;15(3):e70391. doi: 10.1002/brb3.70391.
To explore the effects of craniocervical atherosclerotic stenosis (AS) on the occurrence of neurologic deterioration (ND) in patients with small vessel occlusion (SVO) stroke and the outcomes of patients with SVO stroke with ND (SVO-ND).
Patients with SVO stroke were consecutively enrolled. AS was defined as a craniocervical artery with ≥ 50% stenosis caused by atherosclerosis.
The presence of craniocervical AS (adjusted odds ratio [aOR] = 2.57, 95% confidence interval [CI] = 1.12-5.89, p = 0.026) and the number of craniocervical AS (aOR = 2.08, 95% CI = 1.25-3.44, p = 0.005) were associated with the occurrence of ND in patients with SVO stroke. Compared with SVO stroke patients with no craniocervical AS, the risk of ND increased in those with multiple AS (aOR = 6.47, 95% CI = 1.73-24.05, p = 0.005). The risk of poor outcomes increased in SVO-ND patients with multiple AS than SVO-ND patients with no AS (aOR = 47.75, 95% CI = 1.66-375.17, p = 0.024).
The presence and the number of craniocervical AS are associated with ND in SVO stroke patients and with poststroke disability in SVO-ND patients.
探讨颅颈动脉粥样硬化狭窄（AS）对小血管闭塞（SVO）性卒中患者神经功能恶化（ND）发生情况的影响以及SVO性卒中伴ND（SVO-ND）患者的结局。
连续纳入SVO性卒中患者。AS定义为因动脉粥样硬化导致颅颈动脉狭窄≥50%。
颅颈AS的存在（校正比值比[aOR]=2.57，95%置信区间[CI]=1.12-5.89，p=0.026）和颅颈AS的数量（aOR=2.08，95%CI=1.25-3.44，p=0.005）与SVO性卒中患者ND的发生相关。与无颅颈AS的SVO性卒中患者相比，多发AS患者ND风险增加（aOR=6.47，95%CI=1.73-24.05，p=0.005）。多发AS的SVO-ND患者比无AS的SVO-ND患者不良结局风险增加（aOR=47.75，95%CI=1.66-375.17，p=0.024）。
颅颈AS的存在和数量与SVO性卒中患者的ND以及SVO-ND患者的卒中后残疾相关。
