Clinical Medical College of Yangzhou University, Yangzhou, China.
Department of Neurology, Northern Jiangsu People's Hospital, Yangzhou, China.
Curr Neurovasc Res. 2022;19(1):30-37. doi: 10.2174/1567202619666220214105208.
Receptor-interacting serine-threonine protein kinase 3 (RIP3) was previously discovered to be an important medium in the occurrence and development of major atherosclerotic cerebral infarction. However, the role of RIP3 in acute ischemic stroke remains unclear.
This study aimed to explore the correlation between plasma levels of RIP3 and acute ischemic stroke with large-artery atherosclerosis (LAA).
This prospective study enrolled 116 patients with LAA, 40 healthy controls, and 30 acute ischemic stroke patients with small-artery occlusion. The patients with LAA were divided according to the quartile of plasma levels of RIP3. A logistic regression model was used for comparison. The ROC curve was performed to evaluate the predictive value.
In patients with LAA, the RIP3 levels in patients with poor outcomes as well as neurological deterioration were significantly higher than those with good outcomes (P < 0.001) and without neurological deterioration (P = 0.014). Patients in the highest levels of plasma RIP3 quartile were more likely to have neurological deterioration (OR, 11.07; 95% CI, 1.990-61.582) and poor outcomes (OR, 35.970; 95% CI, 5.392-239.980) compared with the lowest. The optimal cut-off value for neurological deterioration was 1127.75 pg/mL (specificity, 66.7%; sensitivity, 69.2%) and that for poor prognosis was 1181.82 pg/mL (specificity, 89.7%; sensitivity, 62.1%).
Elevated levels of plasma RIP3 were significantly associated with neurological deterioration and poor prognosis in patients with LAA. A significant increase in plasma RIP3 levels can predict neurological deterioration and the poor prognosis of these patients.
受体相互作用丝氨酸/苏氨酸蛋白激酶 3（RIP3）先前被发现是发生和发展主要动脉粥样硬化性脑梗死的重要介质。然而，RIP3 在急性缺血性卒中中的作用尚不清楚。
本研究旨在探讨 RIP3 与大动脉粥样硬化（LAA）性急性缺血性卒中的相关性。
本前瞻性研究纳入了 116 例 LAA 患者、40 例健康对照者和 30 例小动脉闭塞性急性缺血性卒中患者。根据 RIP3 血浆水平的四分位数将 LAA 患者进行分组，采用逻辑回归模型进行比较，ROC 曲线评估预测价值。
在 LAA 患者中，预后不良和神经功能恶化患者的 RIP3 水平显著高于预后良好（P<0.001）和神经功能无恶化（P=0.014）患者。血浆 RIP3 四分位最高水平患者更有可能出现神经功能恶化（OR=11.07；95%CI：1.99061.582）和预后不良（OR=35.97；95%CI：5.392239.98）。神经功能恶化的最佳截断值为 1127.75 pg/mL（特异性为 66.7%，敏感性为 69.2%），预后不良的最佳截断值为 1181.82 pg/mL（特异性为 89.7%，敏感性为 62.1%）。
LAA 患者血浆 RIP3 水平升高与神经功能恶化和预后不良显著相关。血浆 RIP3 水平显著升高可预测这些患者的神经功能恶化和不良预后。
