Wei Haiying, Rui Jinsheng, Yan Xinke, Xu Ruyan, Chen Simeng, Zhang Baiming, Wang Lei, Zhang Zhisong, Zhu Chengwen, Ma Mengtao, Xiao Huining
China Tobacco Jiangsu Industrial Co., Ltd., Nanjing 210019 China; College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037 China.
China Tobacco Jiangsu Industrial Co., Ltd., Nanjing 210019 China.
Food Res Int. 2025 Feb;203:115682. doi: 10.1016/j.foodres.2025.115682. Epub 2025 Jan 16.
Lipid metabolism disorders will trigger various chronic diseases, which posing a serious threat to human health. Therefore, maintaining lipid metabolism balance is a key preventive and therapeutic strategy against various chronic and metabolic diseases. Various researches have proved that plant polyphenols play a significantly important role in regulating lipid metabolism. However, the mechanisms and application challenges of polyphenols in lipid metabolism disorders have rarely been elucidated. This review elucidates the definition, classification and function of plant polyphenols, summarize the kinds of polyphenols that can be used to regulate lipid metabolism, paying particular attention to the mechanisms for regulating lipid metabolism by plant polyphenols. Moreover, the limitations of polyphenols in the regulation of lipid metabolism are described and the trend of their development is prospective. This review will provide guidance to polyphenols in regulating metabolic diseases.
脂质代谢紊乱会引发各种慢性疾病，对人类健康构成严重威胁。因此，维持脂质代谢平衡是预防和治疗各种慢性和代谢性疾病的关键策略。各种研究已证明，植物多酚在调节脂质代谢中发挥着极其重要的作用。然而，多酚在脂质代谢紊乱中的作用机制及应用挑战却鲜有阐明。本综述阐明了植物多酚的定义、分类和功能，总结了可用于调节脂质代谢的多酚种类，特别关注植物多酚调节脂质代谢的机制。此外，还描述了多酚在脂质代谢调节中的局限性，并对其发展趋势进行了展望。本综述将为多酚调节代谢性疾病提供指导。
