Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, School of Food and Health, Beijing Technology & Business University (BTBU), Beijing 100048, China.
School of Regional Innovation and Social Design Engineering, Faculty of Engineering, Kitami Institute of Technology, 165 Koen-cho, Kitami 090-8507, Hokkaido, Japan.
Food Funct. 2024 Aug 12;15(16):8200-8216. doi: 10.1039/d4fo00585f.
The interaction of polyphenols-polysaccharides-gut microbiota to promote health benefits has become a hotspot and direction for precise dietary intervention strategies and foundational research in biomedicine. Both dietary polyphenols and polysaccharides possess biological activities that regulate body health. Single components, due to their inherent structure and physicochemical properties, have a low bioavailability, thus are unable to exert their optimal effects. The compound structure formed by the interaction of polyphenols and polysaccharides can enhance their functional properties, thereby more effectively promoting health benefits and preventing diseases. This review primarily focuses on the roles played by polyphenols and polysaccharides in regulating glucose and lipid metabolism, the improvement of glucose and lipid metabolism through the gut microbial pathway by polyphenols and polysaccharides, and the mechanisms by which polyphenols and polysaccharides interact to regulate glucose and lipid metabolism. A considerable amount of preliminary research has confirmed the regulatory effects of plant polyphenols and polysaccharides on glucose and lipid metabolism. However, studies on the combined effects and mechanisms of these two components are still very limited. This review aims to provide a reference for subsequent research on their interactions and changes in functional properties.
多酚-多糖-肠道微生物群相互作用促进健康益处已成为精准饮食干预策略和生物医学基础研究的热点和方向。膳食多酚和多糖都具有调节身体健康的生物活性。由于其固有结构和物理化学性质，单一成分的生物利用度较低，因此无法发挥最佳效果。多酚和多糖相互作用形成的复合结构可以增强它们的功能特性，从而更有效地促进健康益处和预防疾病。本综述主要关注多酚和多糖在调节葡萄糖和脂质代谢中的作用，多酚和多糖通过肠道微生物途径改善葡萄糖和脂质代谢，以及多酚和多糖相互作用调节葡萄糖和脂质代谢的机制。大量初步研究证实了植物多酚和多糖对葡萄糖和脂质代谢的调节作用。然而，关于这两种成分的联合作用及其机制的研究仍然非常有限。本综述旨在为后续研究它们的相互作用和功能特性变化提供参考。
