School of Chinese Medicine, The University of Hong Kong, Pok Fu Lam, Hong Kong.
Shenzhen Institute of Research and Innovation, Pok Fu Lam, The University of Hong Kong, Hong Kong.
Oxid Med Cell Longev. 2018 Feb 4;2018:8394818. doi: 10.1155/2018/8394818. eCollection 2018.
Liver disease, involving a wide range of liver pathologies from fatty liver, hepatitis, and fibrosis to cirrhosis and hepatocellular carcinoma, is a serious health problem worldwide. In recent years, many natural foods and herbs with abundant phytochemicals have been proposed as health supplementation for patients with hepatic disorders. As an important category of phytochemicals, natural polyphenols have attracted increasing attention as potential agents for the prevention and treatment of liver diseases. The striking capacities in remitting oxidative stress, lipid metabolism, insulin resistance, and inflammation put polyphenols in the spotlight for the therapies of liver diseases. It has been reported that many polyphenols from a wide range of foods and herbs exert therapeutic effects on liver injuries via complicated mechanisms. Therefore, it is necessary to have a systematical review to sort out current researches to help better understand the potentials of polyphenols in liver diseases. In this review, we aim to summarize and update the existing evidence of natural polyphenols in the treatment of various liver diseases by , , and clinical studies, while special attention is paid to the action mechanisms.
肝脏疾病是一个全球性的严重健康问题，涉及多种肝脏病理，包括脂肪肝、肝炎、肝纤维化、肝硬化和肝细胞癌。近年来，许多富含植物化学物质的天然食物和草药被提议作为肝脏疾病患者的健康补充剂。作为植物化学物质的重要类别，天然多酚作为预防和治疗肝脏疾病的潜在药物引起了越来越多的关注。多酚在缓解氧化应激、脂质代谢、胰岛素抵抗和炎症方面的显著能力使其成为肝脏疾病治疗的焦点。据报道，许多来自各种食物和草药的多酚通过复杂的机制对肝损伤发挥治疗作用。因此，有必要进行系统综述，以整理当前的研究，帮助更好地了解多酚在肝脏疾病中的潜力。在本综述中，我们旨在通过动物实验、细胞实验和临床研究总结和更新天然多酚治疗各种肝脏疾病的现有证据，同时特别关注作用机制。
