马洛替酯对乙酰氨基酚诱导的肝毒性的影响。
Effect of malotilate on paracetamol-induced hepatotoxicity.
作者信息
Younes M, Siegers C P
出版信息
Toxicol Lett. 1985 May;25(2):143-6. doi: 10.1016/0378-4274(85)90074-8.
PMID:4002245
Abstract
Malotilate (diisopropyl-1,3-dithiol-2-ylidenemalonate) prevented liver damage induced by paracetamol in male mice only when given 1 h prior to the hepatotoxic agent. Furthermore, it partially inhibited paracetamol-induced glutathione depletion in mouse liver, indicating that the antihepatotoxic activity of malotilate is related to an interaction with the bioactivation of paracetamol.
摘要
马洛替酯（二异丙基-1,3-二硫醇-2-亚基丙二酸酯）仅在肝毒性药物给药前1小时给予时，才能预防扑热息痛诱导的雄性小鼠肝损伤。此外，它部分抑制了扑热息痛诱导的小鼠肝脏谷胱甘肽消耗，表明马洛替酯的抗肝毒性活性与扑热息痛生物活化的相互作用有关。
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