Nokata M, Katoh M, Sugimoto T
J Toxicol Sci. 1985 Nov;10(4):279-88. doi: 10.2131/jts.10.279.
The protective effect of malotilate was studied on the liver injury induced by carbon tetrachloride (CCl4) in mice and rats. Plasma GOT and GPT activities were used as indices for the liver injury, and the liver was histopathologically examined. A remarkable suppressing effect on the liver injury was observed when malotilate was orally given 6 hr prior to oral administration of CCl4 in mice and 3, 6 or 12 hr in rats. Malotilate was also effective in preventing the liver injury caused by intraperitoneal injection of CCl4, indicating that the protective effect is not derived from the decreased CCl4 absorption. The liver injury was suppressed even when malotilate was given 12 or 24 hr prior to oral administration of CCl4 in mice and 24, 48 or 72 hr in rats. It may be the characteristic of malotilate that the protective effect lasts for a long period. It is supposed that the effect is due not only to the inhibition of the metabolic activation of CCl4 but also the other action(s) of malotilate.
研究了马洛替酯对四氯化碳（CCl4）诱导的小鼠和大鼠肝损伤的保护作用。以血浆谷草转氨酶（GOT）和谷丙转氨酶（GPT）活性作为肝损伤指标，并对肝脏进行组织病理学检查。在小鼠中，于口服CCl4前6小时口服马洛替酯，在大鼠中于口服CCl4前3、6或12小时口服马洛替酯时，观察到对肝损伤有显著的抑制作用。马洛替酯对腹腔注射CCl4所致的肝损伤也有效，这表明其保护作用并非源于CCl4吸收减少。在小鼠中，于口服CCl4前12或24小时给予马洛替酯，在大鼠中于口服CCl4前24、48或72小时给予马洛替酯时，肝损伤也受到抑制。保护作用持续较长时间可能是马洛替酯的特性。推测该作用不仅归因于对CCl4代谢活化的抑制，还与马洛替酯的其他作用有关。
