Willcox M C, Björkman A, Brohult J
Trans R Soc Trop Med Hyg. 1985;79(2):242-4. doi: 10.1016/0035-9203(85)90346-3.
Children two to nine years old from an area of holoendemic malaria in northern Liberia had mean HbA2 and haematocrit values significantly (P less than 0.001) lower than others from a neighbouring town where malaria is hypoendemic. After regular administration of chloroquine over two years to 38 children living in a holoendemic village, their mean HbA2 rose from 2.1%, SE +/- 0.04, to 2.6%, SE +/- 0.08 (P less than 0.001) and their mean haematocrit from 0.348, SEM +/- 0.004, to 0.382, SE +/- 0.004 (P less than 0.001), values similar to those of children from the neighbouring town. In another village where chloroquine was not given regularly, mean HbA2, haematocrit and malariometric indices were little changed at the end of the two-year period. We conclude that persistent malarial parasitaemia was the main factor in the relatively low values of the village children. Although it is not clear how malaria depresses HbA, the findings were consistent with the hypothesis that chronic malaria induces iron-deficiency.
来自利比里亚北部疟疾高度流行地区的2至9岁儿童，其平均血红蛋白A2（HbA2）水平和血细胞比容值显著低于（P<0.001）邻近一个疟疾低度流行城镇的儿童。在对一个疟疾高度流行村庄的38名儿童进行了两年的氯喹常规给药后，他们的平均HbA2从2.1%（标准误±0.04）升至2.6%（标准误±0.08）（P<0.001），平均血细胞比容从0.348（标准误±0.004）升至0.382（标准误±0.004）（P<0.001），这些值与邻近城镇儿童的相似。在另一个未定期给予氯喹的村庄，两年结束时平均HbA2、血细胞比容和疟原虫检测指标几乎没有变化。我们得出结论，持续性疟原虫血症是该村儿童上述指标值相对较低的主要因素。虽然尚不清楚疟疾如何降低HbA，但这些发现与慢性疟疾诱发缺铁的假说相符。
