Wang Xilin, Wu Shihai, Guo Ning, Yu Feike, Xu Xiaofeng, Wang Xinghai, Yu Xiaohan, Liu Xiaoye, Dong Hong
Beijing Key Laboratory of Traditional Chinese Veterinary Medicine, Beijing University of Agriculture, Beijing, 102206, China; China Agricultural University, Beijing, 102206, China.
East China Normal University, Shanghai, 200062, China.
Microb Pathog. 2025 May;202:107439. doi: 10.1016/j.micpath.2025.107439. Epub 2025 Feb 27.
The Chinese poultry industry has witnessed rapid development, with laying hens playing a pivotal role. However, the escalating demand has led to an exponential increase in the population of laying hens raised, resulting in emerging challenges. Particularly during bacterial infections, substantial losses can be incurred. Presently, most farms heavily rely on antibiotics for disease prevention and control. Although this approach has yielded positive outcomes, prolonged usage may lead to the emergence of drug-resistant strains and residues. Consequently, research on alternative drugs has been initiated due to antibiotic prohibition and growing pathogen resistance. Chinese herbal medicine holds significant prominence across various domains, including animal husbandry and disease treatment, owing to its traditional roots in China. Scutellaria baicalensis is a traditional Chinese medicine derived from the dried root of the labiatae family plant Scutellaria baicalensis that possesses bitter taste and cold properties while exhibiting effects such as heat clearance, dampness elimination, lung purification, fire expulsion and heat detoxification. The aboveground components of Scutellaria baicalensis encompass stems and leaves, which yield approximately three times more than their root counterparts as traditional Chinese medicine resources. Sculltllarla bactlalensls products have been successfully applied in animal husbandry with therapeutic effects against sore throat, respiratory diseases, and heat detoxification. Therefore, in pursuit of economic sustainability, this study aims at developing an extract from Scutellaria baicalensis stems and leaves for treating respiratory bacterial infections among laying hens. The findings indicate that this extract exhibits excellent therapeutic efficacy against respiratory diseases among laying hens by reducing inflammatory cell levels within their lungs.
中国家禽业发展迅速，蛋鸡发挥着关键作用。然而，需求的不断增加导致饲养蛋鸡数量呈指数级增长，带来了新的挑战。特别是在细菌感染期间，可能会造成重大损失。目前，大多数养殖场严重依赖抗生素进行疾病预防和控制。虽然这种方法取得了积极效果，但长期使用可能导致耐药菌株的出现和残留。因此，由于抗生素禁用和病原体耐药性增加，人们开始研究替代药物。中药在中国有着悠久的传统根基，在包括畜牧业和疾病治疗在内的各个领域都具有重要地位。黄芩是一种来源于唇形科植物黄芩干燥根的传统中药，味苦性寒，具有清热燥湿、清肺泻火、解毒等功效。黄芩的地上部分包括茎和叶，作为中药资源，其产量约为根部的三倍。黄芩产品已成功应用于畜牧业，对治疗喉咙痛、呼吸道疾病和解毒有疗效。因此，为了追求经济可持续性，本研究旨在开发一种黄芩茎叶提取物，用于治疗蛋鸡呼吸道细菌感染。研究结果表明，该提取物通过降低蛋鸡肺部炎症细胞水平，对蛋鸡呼吸道疾病具有优异的治疗效果。
