Kaur Kawaljit, Jewett Anahid
Division of Oral Biology and Medicine, The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, University of California School of Dentistry, 10833 Le Conte Ave., Los Angeles, CA, 90095, USA.
The Jonsson Comprehensive Cancer Center, UCLA School of Dentistry and Medicine, 10833 Le Conte Ave., Los Angeles, CA, 90095, USA.
Cancer Immunol Immunother. 2025 Mar 1;74(4):127. doi: 10.1007/s00262-025-03956-x.
Osteoclasts (OCs) and dendritic cells (DCs) induce expansion and functional activation of NK and T cells. When comparing OCs with DC-induced activation in NK cells, OCs induced significantly higher cell expansion and functional activation of NK cells as compared to DCs, either from healthy individuals or those obtained from cancer patients. However, no differences could be seen in the levels of cell expansion and functional activation in T cells activated by OCs or DCs, either from healthy individuals or those from cancer patients. OCs selectively expanded and activated CD8 + T cells, whereas DCs expanded and activated CD4 + T cells. In addition, both allogeneic and autologous OCs induced similar levels of cell expansion and functional activation of NK and T cells. Together, these findings highlighted the essential roles of OCs in expanding and activating the cytotoxic effectors of NK, and CD8 + T cells, and demonstrated several differences when compared to the effect of DCs.
破骨细胞（OCs）和树突状细胞（DCs）可诱导自然杀伤细胞（NK）和T细胞的扩增及功能激活。在比较OCs与DCs对NK细胞的激活作用时，与来自健康个体或癌症患者的DCs相比，OCs可显著诱导NK细胞更高水平的细胞扩增及功能激活。然而，来自健康个体或癌症患者的OCs或DCs激活的T细胞在细胞扩增水平和功能激活方面未见差异。OCs选择性地扩增并激活CD8+ T细胞，而DCs扩增并激活CD4+ T细胞。此外，同种异体和自体OCs诱导的NK细胞和T细胞的细胞扩增水平及功能激活相似。总之，这些发现突出了OCs在扩增和激活NK细胞及CD8+ T细胞的细胞毒性效应器方面的重要作用，并显示出与DCs作用相比的若干差异。
