Ou Lingling, He Lulu, Bu Qiaowen, Wu Hengying, Wen Bin, Luo Xiping, Hong Xiaoshan
Department of Gynecology, Guangdong Women and Children Hospital, Guangzhou, China.
Jiangmen People's Hospita, Jiangmen, China.
J Cancer Res Clin Oncol. 2025 Mar 1;151(3):97. doi: 10.1007/s00432-025-06139-4.
To evaluate the 5-year survival rates of patients with early cervical cancer (CC) under different surgical approaches and to analyze the factors affecting the prognosis of these patients.
A retrospective analysis and follow-up study were conducted on patients who underwent surgical treatment for early CC at Guangdong Women and Children Hospital between January 2005 and December 2017. Prognostic factors were analyzed using the Kaplan-Meier method and Cox regression model.
A total of 726 patients were included, with 347 in the open surgery group and 379 in the laparoscopy group. The proportion of deep stromal infiltration in the open group was significantly higher than in the laparoscopy group (228/347 vs. 194/379, respectively; P < 0.05). Similarly, the tumor diameter (< 4 cm) was significantly larger in the open group compared to the laparoscopy group (51/347 vs. 26/379, respectively; P < 0.05). There were no statistically significant differences between the two groups in terms of the number of pregnancies, number of deliveries, menopause, contraceptive methods, high-risk HPV infection, clinical stage, pathological type, degree of differentiation, parametrial invasion, or lymph node metastasis (P > 0.05). The mean follow-up period was 53.15 ± 15.33 months. The overall 5-year survival rate (OS) for all patients was 89.0%, while the disease-free survival rate (DFS) was 86.8%. The 5-year OS rates in the open and laparoscopy groups were 87.2% and 90.4%, respectively, while the 5-year DFS rates were 84.6% and 88.6%, respectively, with no statistically significant differences between the groups (P > 0.05). Multivariate analysis revealed that clinical stage, vascular invasion, and tumor diameter were independent risk factors affecting survival and prognosis in patients with CC. However, the surgical approach did not significantly influence prognosis.
The 5-year overall survival rate of patients with early CC was 89.0%. Laparoscopic surgery did not adversely affect the prognosis of early CC patients. Both surgical approaches demonstrate favorable prospects for treating early CC. Prognosis in early CC is influenced by clinical stage, vascular invasion, and tumor diameter, rather than the surgical approach used.
评估不同手术方式下早期宫颈癌（CC）患者的5年生存率，并分析影响这些患者预后的因素。
对2005年1月至2017年12月在广东省妇女儿童医院接受早期CC手术治疗的患者进行回顾性分析和随访研究。采用Kaplan-Meier法和Cox回归模型分析预后因素。
共纳入726例患者，其中开放手术组347例，腹腔镜组379例。开放组深层间质浸润的比例显著高于腹腔镜组（分别为228/347和194/379；P＜0.05）。同样，开放组的肿瘤直径（＜4 cm）显著大于腹腔镜组（分别为51/347和26/379；P＜0.05）。两组在妊娠次数、分娩次数、绝经情况、避孕方法、高危型人乳头瘤病毒感染、临床分期、病理类型、分化程度、宫旁浸润或淋巴结转移方面无统计学显著差异（P＞0.05）。平均随访期为53.15±15.33个月。所有患者的总体5年生存率（OS）为89.0%，无病生存率（DFS）为86.8%。开放组和腹腔镜组的5年OS率分别为87.2%和90.4%，5年DFS率分别为84.6%和88.6%，两组间无统计学显著差异（P＞0.05）。多因素分析显示，临床分期、血管侵犯和肿瘤直径是影响CC患者生存和预后的独立危险因素。然而，手术方式对预后没有显著影响。
早期CC患者的5年总生存率为89.0%。腹腔镜手术对早期CC患者的预后没有不利影响。两种手术方式在治疗早期CC方面均显示出良好的前景。早期CC的预后受临床分期、血管侵犯和肿瘤直径的影响，而非所采用的手术方式。
