Farsad Faraneh, Salimpour Sara, Mirhashemi Seyedhadi, Jolfaei Pardis, Erfanifar Azam, Toreyhi Hossein, Davoudi Zahra
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Obes Surg. 2025 Apr;35(4):1307-1315. doi: 10.1007/s11695-025-07746-3. Epub 2025 Mar 3.
Obesity is commonly linked with a pro-inflammatory condition, marked by elevated levels of inflammatory biomarkers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Sleeve gastrectomy, a widely utilized bariatric procedure, aims to achieve substantial weight loss and enhance metabolic function. This study aims to examine the impact of body mass index (BMI) reduction following sleeve gastrectomy on the levels of inflammatory markers CRP and ESR in obese individuals.
A prospective observational study was carried out on patients with obesity who underwent sleeve gastrectomy between 2020 and 2022 at Luqman Hakim Medical Education Center. CRP and ESR levels were recorded preoperatively and then at 6- and 12-month post-surgery. Simple regression analysis was employed to evaluate the correlation between BMI reduction and changes in CRP and ESR levels over time.
A significant reduction in BMI, CRP, and ESR levels was observed at both 6- and 12-month post-surgery. However, regression analysis indicated that BMI reduction did not significantly predict changes in ESR (B = 0.209, p = 0.262) or CRP (B = 0.274, p = 0.079) at the 6-month and 12-month follow-ups (CRP: B = 0.123, p = 0.138; ESR: B = 0.122, p = 0.453).
While sleeve gastrectomy significantly reduces BMI and inflammatory markers such as CRP and ESR in patients with obesity, the direct association between BMI reduction and these markers was not statistically significant. Further studies are warranted to elucidate the underlying mechanisms and identify other potential predictors of inflammatory marker reduction post-surgery.
肥胖通常与促炎状态相关，其特征是炎症生物标志物如C反应蛋白（CRP）和红细胞沉降率（ESR）水平升高。袖状胃切除术是一种广泛应用的减肥手术，旨在实现显著的体重减轻并改善代谢功能。本研究旨在探讨肥胖个体接受袖状胃切除术后体重指数（BMI）降低对炎症标志物CRP和ESR水平的影响。
对2020年至2022年在鲁克曼·哈基姆医学教育中心接受袖状胃切除术的肥胖患者进行了一项前瞻性观察研究。术前及术后6个月和12个月记录CRP和ESR水平。采用简单回归分析来评估BMI降低与CRP和ESR水平随时间变化之间的相关性。
术后6个月和12个月时，BMI、CRP和ESR水平均显著降低。然而，回归分析表明，在6个月和12个月的随访中，BMI降低并不能显著预测ESR（B = 0.209，p = 0.262）或CRP（B = 0.274，p = 0.079）的变化（CRP：B = 0.123，p = 0.138；ESR：B = 0.122，p = 0.453）。
虽然袖状胃切除术可显著降低肥胖患者的BMI以及CRP和ESR等炎症标志物，但BMI降低与这些标志物之间的直接关联在统计学上并不显著。有必要进行进一步研究以阐明潜在机制，并确定术后炎症标志物降低的其他潜在预测因素。
