Patschan Daniel, Stasche Friedrich, Erfurt Stefan, Matyukhin Igor, Ritter Oliver, Safi Wajima
Department of Internal Medicine I - Cardiology, Nephrology and Internal Intensive Care Medicine, University Hospital Brandenburg, Brandenburg Medical School (Theodor Fontane), Hochstraße 29, 14770, Brandenburg an der Havel, Brandenburg, Germany.
J Nephrol. 2025 Mar;38(2):445-456. doi: 10.1007/s40620-025-02220-w. Epub 2025 Mar 1.
Acute kidney injury (AKI) is associated with a significant burden of mortality worldwide. Each episode of AKI increases the long-term risk of death, especially if there is no recovery or insufficient renal recovery (i.e. restoration of kidney function). This narrative review summarizes relevant studies on the definition and prediction of renal recovery. The following databases were searched for references: PubMed, Web of Science, Cochrane Library, Scopus. The period lasted from 1990 until 2024. The currently available criteria for renal recovery have been identified and discussed. Regarding restoration of kidney function prediction, seven studies on alternative or novel biomarkers have been reviewed. In the context of kidney replacement therapy and renal recovery, findings from four large, prospective randomized studies have been summarized. A standardized definition of renal recovery is presently not available. Specific biomarkers allow for an estimation of the likelihood of renal recovery under certain conditions. According to current knowledge, no dialysis method has been definitively shown to be advantageous for the recovery process.
急性肾损伤（AKI）在全球范围内与严重的死亡负担相关。每一次AKI发作都会增加长期死亡风险，尤其是在肾功能没有恢复或恢复不充分（即肾功能恢复）的情况下。这篇叙述性综述总结了关于肾功能恢复的定义和预测的相关研究。检索了以下数据库以获取参考文献：PubMed、科学网、考克兰图书馆、Scopus。时间跨度从1990年至2024年。已确定并讨论了目前可用的肾功能恢复标准。关于肾功能恢复预测，已对七项关于替代或新型生物标志物的研究进行了综述。在肾脏替代治疗和肾功能恢复的背景下，总结了四项大型前瞻性随机研究的结果。目前尚无肾功能恢复的标准化定义。特定生物标志物可用于估计在某些条件下肾功能恢复的可能性。根据目前的知识，尚无明确证据表明哪种透析方法对恢复过程有利。
