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姜黄诱导的肝损伤。

Turmeric-Induced Liver Injury.

作者信息

Abboud Alan, Ullah Kazi, Klyachman Leslie, Huang Emily B, Cherala Rasan

机构信息

Department of Medicine Stony Brook University Hospital.

Division of Gastroenterology, Department of Medicine Stony Brook University Hospital.

出版信息

J Brown Hosp Med. 2024 Oct 1;3(4):21-24. doi: 10.56305/001c.122729. eCollection 2024.

DOI:10.56305/001c.122729
PMID:40026546
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11864403/
Abstract

Turmeric and its active compound, curcumin, has gained popularity as an herbal supplement due to its anti-inflammatory properties. However, the lack of standardized regulation for herbal supplements raises concerns about potential side effects and toxicity. This case report presents a 53-year-old woman with Behçet disease who developed biopsy-proven drug-induced liver injury (DILI) after initiating a turmeric supplement, with resolution of laboratory abnormalities after a positive supplement de-challenge. This case highlights the importance of noting herbal supplementation during medication reconciliation and underscores the need for rigorous regulatory oversight to ensure the safety of such products.

摘要

姜黄及其活性成分姜黄素,因其抗炎特性作为一种草药补充剂而受到欢迎。然而,草药补充剂缺乏标准化监管引发了对潜在副作用和毒性的担忧。本病例报告介绍了一名53岁患有白塞病的女性,在开始服用姜黄补充剂后出现了经活检证实的药物性肝损伤(DILI),在停用补充剂后实验室异常情况得到缓解。本病例强调了在用药核对时记录草药补充剂使用情况的重要性,并强调需要进行严格的监管监督以确保此类产品的安全性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f8e/11864403/7bdbd6d1dcb4/bhm_2024_3_4_122729_242533.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f8e/11864403/fbda58d0692f/bhm_2024_3_4_122729_242532.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f8e/11864403/7bdbd6d1dcb4/bhm_2024_3_4_122729_242533.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f8e/11864403/fbda58d0692f/bhm_2024_3_4_122729_242532.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f8e/11864403/7bdbd6d1dcb4/bhm_2024_3_4_122729_242533.jpg

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本文引用的文献

1
The Evolving Profile of Idiosyncratic Drug-Induced Liver Injury.特发性药物性肝损伤的演变特征。
Clin Gastroenterol Hepatol. 2023 Jul;21(8):2088-2099. doi: 10.1016/j.cgh.2022.12.040. Epub 2023 Mar 1.
2
Liver Injury Associated with Turmeric-A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN].与姜黄相关的肝损伤:药物性肝损伤网络(DILIN)的 10 个病例报告。
Am J Med. 2023 Feb;136(2):200-206. doi: 10.1016/j.amjmed.2022.09.026. Epub 2022 Oct 14.
3
Role of N-acetylcysteine in non-acetaminophen-related acute liver failure: an updated meta-analysis and systematic review.
N-乙酰半胱氨酸在非对乙酰氨基酚相关急性肝衰竭中的作用:一项更新的荟萃分析和系统评价
Ann Gastroenterol. 2021;34(2):235-240. doi: 10.20524/aog.2021.0571. Epub 2021 Jan 4.
4
Turmeric (Curcuma longa L.) food supplements and hepatotoxicity: an integrated evaluation approach.姜黄(姜黄属长根姜)食品补充剂和肝毒性:一种综合评估方法。
Ann Ist Super Sanita. 2020 Oct-Dec;56(4):462-469. doi: 10.4415/ANN_20_04_08.
5
Acute liver injury following turmeric use in Tuscany: An analysis of the Italian Phytovigilance database and systematic review of case reports.托斯卡纳地区使用姜黄导致的急性肝损伤:意大利植物药物警戒数据库分析和病例报告系统评价。
Br J Clin Pharmacol. 2021 Mar;87(3):741-753. doi: 10.1111/bcp.14460. Epub 2020 Jul 20.
6
Curcumin in Combination With Mesalamine Induces Remission in Patients With Mild-to-Moderate Ulcerative Colitis in a Randomized Controlled Trial.姜黄素联合美沙拉嗪治疗轻中度溃疡性结肠炎的随机对照试验
Clin Gastroenterol Hepatol. 2015 Aug;13(8):1444-9.e1. doi: 10.1016/j.cgh.2015.02.019. Epub 2015 Feb 24.
7
Renoprotective effect of the antioxidant curcumin: Recent findings.抗氧化剂姜黄素的肾脏保护作用:最新研究结果
Redox Biol. 2013 Sep 17;1(1):448-56. doi: 10.1016/j.redox.2013.09.003.
8
Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.抗炎剂姜黄素对神经退行性疾病、心血管疾病、肺部疾病、代谢性疾病、自身免疫性疾病和肿瘤性疾病的潜在治疗作用。
Int J Biochem Cell Biol. 2009 Jan;41(1):40-59. doi: 10.1016/j.biocel.2008.06.010. Epub 2008 Jul 9.