Cadmus Simeon, Akinseye Victor Oluwatoyin, Olagunju Temitayo, Makolo Angela, Falodun Olutayo, Lawal Oluwole, Babalola John, Cadmus Eniola, Yasir Othman, Fadeyi Muse, Ahmed Bolaji, Piubello Alberto, Ortuno Guiterrez Nimer, El-Tayeb Osman
Department of Veterinary Public Health and Preventive Medicine, University of Ibadan, Ibadan, Nigeria.
Damien Foundation Genomics and Mycobacteria Research and Training Centre, University of Ibadan, Ibadan, Nigeria.
Pan Afr Med J. 2024 Nov 22;49:87. doi: 10.11604/pamj.2024.49.87.43958. eCollection 2024.
tuberculosis (TB) remains a disease of global health importance. GeneXpert has emerged as a useful tool for the diagnosis of drug resistant TB (DR-TB). We determined the risk factors associated with DR-TB among presumptive pulmonary TB patients.
a cross-sectional study was conducted among presumptive TB patients attending Directly Observed Treatments (DOTs) centres in Southwestern Nigeria. Sputum samples were obtained from individuals with suspected pulmonary TB, subjected to GeneXpert as the first-line test and then culture. Data were analysed using STATA 12.
sputum samples were collected from 2,169 consecutive patients and processed. A greater proportion of the participants (52.14%) were female, most within the age range of 20-39 (38.36%) and 40-59 (36.93%) years. About two-thirds, 66.34% (1439/2169) were GeneXpert positive and of this, 47 (3.27%) were DR-TB. Overall, 44.04% (855/2169) samples were culture positive. 7.56% of the patients were HIV positive, while 19.50%, 1.52% and 61.96% were new, relapse and previously treated cases, respectively. Multivariate analysis identified case definition (OR=2.38; 95%CI: 1.92-3.03) and (OR= 8.33; 95%CI: 5.26-12.50) and HIV (OR= 1.85; 95%CI: 1.29-2.65) and (OR= 3.61; 95%CI: 2.59-5.02) based on GeneXpert and culture as important risk factors for TB and DR-TB infection among participants.
we found a moderate level prevalence of DR-TB with gender, previous TB treatments, and HIV status as major factors associated with DR-TB among study participants.
结核病仍然是一个具有全球健康重要性的疾病。Xpert MTB/RIF已成为诊断耐多药结核病（DR-TB）的有用工具。我们确定了疑似肺结核患者中与耐多药结核病相关的危险因素。
在尼日利亚西南部接受直接观察治疗（DOTs）中心的疑似结核病患者中进行了一项横断面研究。从疑似肺结核患者中获取痰标本，首先进行Xpert MTB/RIF检测，然后进行培养。使用STATA 12对数据进行分析。
收集并处理了2169例连续患者的痰标本。参与者中女性比例更高（52.14%），大多数年龄在20-39岁（38.36%）和40-59岁（36.93%）之间。约三分之二（66.34%，1439/2169）的患者Xpert MTB/RIF检测呈阳性，其中47例（3.27%）为耐多药结核病。总体而言，44.04%（855/2169）的样本培养呈阳性。7.56%的患者HIV检测呈阳性，而新发病例、复发病例和既往治疗病例分别占19.50%、1.52%和61.96%。多变量分析确定，基于Xpert MTB/RIF和培养结果的病例定义（OR=2.38；95%CI：1.92-3.03）以及HIV（OR=1.85；95%CI：1.29-2.
